Prospective evaluation of thyroid function in patients with systemic sclerosis (scleroderma)

Leslie Kahl, T. A. Medsger, I. Klein

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

A consecutive series of 77 ambulatory, clinically euthyroid patients with systemic sclerosis was evaluated for clinical, chemical and serologic evidence of thyroid disease. Measurements of baseline serum thyroid function tests and the thyroid stimulating hormone response to thyrotropin releasing hormone (TRH) were made. We classified 18 (23%) patients as abnormal, including 8 (10%) who were chemically hypothyroid and 10 (13%) with normal baseline studies but an exaggerated response to TRH injection. The remaining 59 (77%) patients were euthyroid by all measurements. Antithyroid antibodies were present in only 4 of 8 (50%) of the hypothyroid group. There were no differences between the 3 patient groups with regard to the extent of scleroderma, the presence of internal organ involvement, or the frequency of common signs or symptoms of hypothyroidism. Abnormal thyroid function in systemic sclerosis is frequent, often unsuspected clinically, and may occur without markers of autoimmune thyroid disease.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalJournal of Rheumatology
Volume13
Issue number1
StatePublished - 1986
Externally publishedYes

Fingerprint

Systemic Scleroderma
Thyroid Gland
Thyrotropin-Releasing Hormone
Thyroid Diseases
Thyroid Function Tests
Thyrotropin
Hypothyroidism
Autoimmune Diseases
Signs and Symptoms
Injections
Antibodies
Serum

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Prospective evaluation of thyroid function in patients with systemic sclerosis (scleroderma). / Kahl, Leslie; Medsger, T. A.; Klein, I.

In: Journal of Rheumatology, Vol. 13, No. 1, 1986, p. 103-107.

Research output: Contribution to journalArticle

@article{49149c57c5cb424ea6466c3da6cb4762,
title = "Prospective evaluation of thyroid function in patients with systemic sclerosis (scleroderma)",
abstract = "A consecutive series of 77 ambulatory, clinically euthyroid patients with systemic sclerosis was evaluated for clinical, chemical and serologic evidence of thyroid disease. Measurements of baseline serum thyroid function tests and the thyroid stimulating hormone response to thyrotropin releasing hormone (TRH) were made. We classified 18 (23{\%}) patients as abnormal, including 8 (10{\%}) who were chemically hypothyroid and 10 (13{\%}) with normal baseline studies but an exaggerated response to TRH injection. The remaining 59 (77{\%}) patients were euthyroid by all measurements. Antithyroid antibodies were present in only 4 of 8 (50{\%}) of the hypothyroid group. There were no differences between the 3 patient groups with regard to the extent of scleroderma, the presence of internal organ involvement, or the frequency of common signs or symptoms of hypothyroidism. Abnormal thyroid function in systemic sclerosis is frequent, often unsuspected clinically, and may occur without markers of autoimmune thyroid disease.",
author = "Leslie Kahl and Medsger, {T. A.} and I. Klein",
year = "1986",
language = "English (US)",
volume = "13",
pages = "103--107",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology",
number = "1",

}

TY - JOUR

T1 - Prospective evaluation of thyroid function in patients with systemic sclerosis (scleroderma)

AU - Kahl, Leslie

AU - Medsger, T. A.

AU - Klein, I.

PY - 1986

Y1 - 1986

N2 - A consecutive series of 77 ambulatory, clinically euthyroid patients with systemic sclerosis was evaluated for clinical, chemical and serologic evidence of thyroid disease. Measurements of baseline serum thyroid function tests and the thyroid stimulating hormone response to thyrotropin releasing hormone (TRH) were made. We classified 18 (23%) patients as abnormal, including 8 (10%) who were chemically hypothyroid and 10 (13%) with normal baseline studies but an exaggerated response to TRH injection. The remaining 59 (77%) patients were euthyroid by all measurements. Antithyroid antibodies were present in only 4 of 8 (50%) of the hypothyroid group. There were no differences between the 3 patient groups with regard to the extent of scleroderma, the presence of internal organ involvement, or the frequency of common signs or symptoms of hypothyroidism. Abnormal thyroid function in systemic sclerosis is frequent, often unsuspected clinically, and may occur without markers of autoimmune thyroid disease.

AB - A consecutive series of 77 ambulatory, clinically euthyroid patients with systemic sclerosis was evaluated for clinical, chemical and serologic evidence of thyroid disease. Measurements of baseline serum thyroid function tests and the thyroid stimulating hormone response to thyrotropin releasing hormone (TRH) were made. We classified 18 (23%) patients as abnormal, including 8 (10%) who were chemically hypothyroid and 10 (13%) with normal baseline studies but an exaggerated response to TRH injection. The remaining 59 (77%) patients were euthyroid by all measurements. Antithyroid antibodies were present in only 4 of 8 (50%) of the hypothyroid group. There were no differences between the 3 patient groups with regard to the extent of scleroderma, the presence of internal organ involvement, or the frequency of common signs or symptoms of hypothyroidism. Abnormal thyroid function in systemic sclerosis is frequent, often unsuspected clinically, and may occur without markers of autoimmune thyroid disease.

UR - http://www.scopus.com/inward/record.url?scp=0022587313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022587313&partnerID=8YFLogxK

M3 - Article

C2 - 3701723

AN - SCOPUS:0022587313

VL - 13

SP - 103

EP - 107

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 1

ER -