Prospective determination of distal colon findings in average-risk patients with proximal colon cancer

D. K. Rex, A. Chak, R. Vasudeva, T. Gross, David Lieberman, I. Bhattacharya, E. Sack, M. Wiersema, F. Farraye, M. Wallace, D. Barrido, E. Cravens, L. Zeabart, D. Bjorkman, T. Lemmel, S. Buckley

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Background: Recent guidelines indicate that colonoscopy and sigmoidoscopy are both acceptable options for screening average-risk patients for colorectal cancer. Retrospective studies have found that a majority of patients with cancer proximal to the splenic flexure have a normal screening flexible sigmoidoscopy. Methods: This was a multicenter, prospective description of colonoscopic findings and family history in consecutive patients with proximal colon cancer. Results: Among 116 prospectively identified average-risk patients with cancer proximal to the splenic flexure, 40 (34.5%) had neoplasia distal to the splenic flexure. The prevalence of patients with adenomas greater than or equal to 1 cm, with only one tubular adenoma less than 1 cm, and with only hyperplastic polyps were 16.4%, 8.6%, and 6.9%, respectively. Conclusions: Most average-risk patients with cancer proximal to the splenic flexure will have a normal screening flexible sigmoidoscopy. These patients have an unexpectedly high prevalence of large distal adenomas, but the prevalence of both single small tubular adenomas and hyperplastic polyps alone is similar to that expected during screening of the general population. Clinicians and payers should continue to seek methods to improve the cost-effectiveness and availability of screening colonoscopy in average-risk persons.

Original languageEnglish (US)
Pages (from-to)727-730
Number of pages4
JournalGastrointestinal Endoscopy
Volume49
Issue number6
DOIs
StatePublished - 1999
Externally publishedYes

Fingerprint

Colonic Neoplasms
Colon
Transverse Colon
Sigmoidoscopy
Adenoma
Colonoscopy
Polyps
Neoplasms
Cost-Benefit Analysis
Colorectal Neoplasms
Retrospective Studies
Guidelines
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prospective determination of distal colon findings in average-risk patients with proximal colon cancer. / Rex, D. K.; Chak, A.; Vasudeva, R.; Gross, T.; Lieberman, David; Bhattacharya, I.; Sack, E.; Wiersema, M.; Farraye, F.; Wallace, M.; Barrido, D.; Cravens, E.; Zeabart, L.; Bjorkman, D.; Lemmel, T.; Buckley, S.

In: Gastrointestinal Endoscopy, Vol. 49, No. 6, 1999, p. 727-730.

Research output: Contribution to journalArticle

Rex, DK, Chak, A, Vasudeva, R, Gross, T, Lieberman, D, Bhattacharya, I, Sack, E, Wiersema, M, Farraye, F, Wallace, M, Barrido, D, Cravens, E, Zeabart, L, Bjorkman, D, Lemmel, T & Buckley, S 1999, 'Prospective determination of distal colon findings in average-risk patients with proximal colon cancer', Gastrointestinal Endoscopy, vol. 49, no. 6, pp. 727-730. https://doi.org/10.1016/S0016-5107(99)70290-7
Rex, D. K. ; Chak, A. ; Vasudeva, R. ; Gross, T. ; Lieberman, David ; Bhattacharya, I. ; Sack, E. ; Wiersema, M. ; Farraye, F. ; Wallace, M. ; Barrido, D. ; Cravens, E. ; Zeabart, L. ; Bjorkman, D. ; Lemmel, T. ; Buckley, S. / Prospective determination of distal colon findings in average-risk patients with proximal colon cancer. In: Gastrointestinal Endoscopy. 1999 ; Vol. 49, No. 6. pp. 727-730.
@article{762c42e466f245fdac8b99ba244753d6,
title = "Prospective determination of distal colon findings in average-risk patients with proximal colon cancer",
abstract = "Background: Recent guidelines indicate that colonoscopy and sigmoidoscopy are both acceptable options for screening average-risk patients for colorectal cancer. Retrospective studies have found that a majority of patients with cancer proximal to the splenic flexure have a normal screening flexible sigmoidoscopy. Methods: This was a multicenter, prospective description of colonoscopic findings and family history in consecutive patients with proximal colon cancer. Results: Among 116 prospectively identified average-risk patients with cancer proximal to the splenic flexure, 40 (34.5{\%}) had neoplasia distal to the splenic flexure. The prevalence of patients with adenomas greater than or equal to 1 cm, with only one tubular adenoma less than 1 cm, and with only hyperplastic polyps were 16.4{\%}, 8.6{\%}, and 6.9{\%}, respectively. Conclusions: Most average-risk patients with cancer proximal to the splenic flexure will have a normal screening flexible sigmoidoscopy. These patients have an unexpectedly high prevalence of large distal adenomas, but the prevalence of both single small tubular adenomas and hyperplastic polyps alone is similar to that expected during screening of the general population. Clinicians and payers should continue to seek methods to improve the cost-effectiveness and availability of screening colonoscopy in average-risk persons.",
author = "Rex, {D. K.} and A. Chak and R. Vasudeva and T. Gross and David Lieberman and I. Bhattacharya and E. Sack and M. Wiersema and F. Farraye and M. Wallace and D. Barrido and E. Cravens and L. Zeabart and D. Bjorkman and T. Lemmel and S. Buckley",
year = "1999",
doi = "10.1016/S0016-5107(99)70290-7",
language = "English (US)",
volume = "49",
pages = "727--730",
journal = "Gastrointestinal Endoscopy",
issn = "0016-5107",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - Prospective determination of distal colon findings in average-risk patients with proximal colon cancer

AU - Rex, D. K.

AU - Chak, A.

AU - Vasudeva, R.

AU - Gross, T.

AU - Lieberman, David

AU - Bhattacharya, I.

AU - Sack, E.

AU - Wiersema, M.

AU - Farraye, F.

AU - Wallace, M.

AU - Barrido, D.

AU - Cravens, E.

AU - Zeabart, L.

AU - Bjorkman, D.

AU - Lemmel, T.

AU - Buckley, S.

PY - 1999

Y1 - 1999

N2 - Background: Recent guidelines indicate that colonoscopy and sigmoidoscopy are both acceptable options for screening average-risk patients for colorectal cancer. Retrospective studies have found that a majority of patients with cancer proximal to the splenic flexure have a normal screening flexible sigmoidoscopy. Methods: This was a multicenter, prospective description of colonoscopic findings and family history in consecutive patients with proximal colon cancer. Results: Among 116 prospectively identified average-risk patients with cancer proximal to the splenic flexure, 40 (34.5%) had neoplasia distal to the splenic flexure. The prevalence of patients with adenomas greater than or equal to 1 cm, with only one tubular adenoma less than 1 cm, and with only hyperplastic polyps were 16.4%, 8.6%, and 6.9%, respectively. Conclusions: Most average-risk patients with cancer proximal to the splenic flexure will have a normal screening flexible sigmoidoscopy. These patients have an unexpectedly high prevalence of large distal adenomas, but the prevalence of both single small tubular adenomas and hyperplastic polyps alone is similar to that expected during screening of the general population. Clinicians and payers should continue to seek methods to improve the cost-effectiveness and availability of screening colonoscopy in average-risk persons.

AB - Background: Recent guidelines indicate that colonoscopy and sigmoidoscopy are both acceptable options for screening average-risk patients for colorectal cancer. Retrospective studies have found that a majority of patients with cancer proximal to the splenic flexure have a normal screening flexible sigmoidoscopy. Methods: This was a multicenter, prospective description of colonoscopic findings and family history in consecutive patients with proximal colon cancer. Results: Among 116 prospectively identified average-risk patients with cancer proximal to the splenic flexure, 40 (34.5%) had neoplasia distal to the splenic flexure. The prevalence of patients with adenomas greater than or equal to 1 cm, with only one tubular adenoma less than 1 cm, and with only hyperplastic polyps were 16.4%, 8.6%, and 6.9%, respectively. Conclusions: Most average-risk patients with cancer proximal to the splenic flexure will have a normal screening flexible sigmoidoscopy. These patients have an unexpectedly high prevalence of large distal adenomas, but the prevalence of both single small tubular adenomas and hyperplastic polyps alone is similar to that expected during screening of the general population. Clinicians and payers should continue to seek methods to improve the cost-effectiveness and availability of screening colonoscopy in average-risk persons.

UR - http://www.scopus.com/inward/record.url?scp=0032998191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032998191&partnerID=8YFLogxK

U2 - 10.1016/S0016-5107(99)70290-7

DO - 10.1016/S0016-5107(99)70290-7

M3 - Article

VL - 49

SP - 727

EP - 730

JO - Gastrointestinal Endoscopy

JF - Gastrointestinal Endoscopy

SN - 0016-5107

IS - 6

ER -