Ten unselected, apparently healthy short children who were capable of normal growth hormone secretion were given human growth hormone (0.1 U/kg im thrice weekly) for 6 months to determine whether such treatment might lead to an increase in growth velocity. During treatment, all patients increased their growth rate (from 4.3±0.3 cm/yr to 7.4±0.5 cm/yr P<0.001). No adverse effects were deteced. During the four-day IGF generation test, IGF I and IGF II levels rose significantly from 0.32±0.04 U/ml to 0.62±0.13 U/ml and from 279±36 ng/ml to 434±49 ng/ml, respectively. However, the growth response was not predicted by either the acute rise in IGF I or that in IGF II. Human growth hormone in standard doses may be capable of inducing accelerated growth in some short children without growth hormone deficiency. Measurements of IGF I and II cannot be used to predict which children will respond.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health