Proptosis caused by rhabdomyomatous mesenchymal hamartomata occurring in the orbit

Isabella T. Phan, R. Jackson Courtney, Douglas P. Marx, David Wilson, Atiya Mansoor, John Ng

Research output: Contribution to journalArticle

Abstract

Two infants were referred for progressive orbital proptosis. MRI in both cases demonstrated a homogenous mass in the orbit adherent to and isointense with a rectus muscle. Histopathology in both cases demonstrated a bland proliferation of spindle cells with entrapped skeletal muscle. Immunochemistry demonstrated that the abnormal tissue was of skeletal muscle origin, consistent with rhabdomyomatous mesenchymal hamartoma (RMH). Observation was elected due to the reported benign nature of RMH. In contrast to RMH of the cutaneous tissues that typically follows a benign course, RMH of the orbit may present with rapid growth.

Original languageEnglish (US)
JournalOphthalmic Plastic and Reconstructive Surgery
DOIs
StateAccepted/In press - Aug 7 2014

Fingerprint

Exophthalmos
Hamartoma
Orbit
Skeletal Muscle
Immunochemistry
Cell Proliferation
Observation
Muscles
Skin
Growth

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Proptosis caused by rhabdomyomatous mesenchymal hamartomata occurring in the orbit. / Phan, Isabella T.; Courtney, R. Jackson; Marx, Douglas P.; Wilson, David; Mansoor, Atiya; Ng, John.

In: Ophthalmic Plastic and Reconstructive Surgery, 07.08.2014.

Research output: Contribution to journalArticle

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