Proprotein convertase genes in Xenopus development

Sylvia Nelsen, Linnea Berg, Crispin Wong, Jan L. Christian

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Proprotein convertases (PCs) are a family of serine endoproteases that proteolytically activate many precursor proteins within various secretory pathway compartments. Loss-of-function studies have demonstrated a critical role for these proteases in embryonic patterning and adult homeostasis, yet little is known about how substrate selectivity is achieved. We have identified Xenopus orthologs of three PCs: furin, PC6, and PC4. In addition to previously described isoforms of PC6 and furin, four novel splice isoforms of PC6, which are predicted to encode constitutively secreted proteases, and a putative transmembrane isoform of PC4 were identified. Furin and PC6 are expressed in dynamic, tissue-specific patterns throughout embryogenesis, whereas PC4 transcripts are restricted primarily to germ cells and brain in adult frogs.

Original languageEnglish (US)
Pages (from-to)1038-1044
Number of pages7
JournalDevelopmental Dynamics
Volume233
Issue number3
DOIs
StatePublished - Jul 2005

Keywords

  • Embryogenesis
  • Furin
  • PC4
  • PC6
  • Proprotein convertase
  • Xenopus

ASJC Scopus subject areas

  • Developmental Biology

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