Propofol for sedation in neuro-intensive care

Michael P. Hutchens, Stavros Memtsoudis, Nicholas Sadovnikoff

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Interventions in the intensive care unit often require that the patient be sedated. Propofol is a widely used, potent sedative agent that is popular in critical care and operating room settings. In addition to its sedative qualities, propofol has neurovascular, neuroprotective, and electroencephalographical effects that are salutory in the patient in neurocritical care. However, the 15-year experience with this agent has not been entirely unbesmirched by controversy: propofol also has important adverse effects that must be carefully considered. This article discusses and reviews the pharmacology of propofol, with specific emphasis on its use as a sedative in the neuro-intensive care unit. A detailed explanation of central nervous system and cardiovascular mechanisms is presented. Additionally, the article reviews the literature specifically pertaining to neurocritical care use of propofol.

Original languageEnglish (US)
Pages (from-to)54-62
Number of pages9
JournalNeurocritical Care
Issue number1
StatePublished - Feb 2006


  • Critical care medicine
  • Neurocritical care
  • Propofol

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


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