TY - JOUR
T1 - Prophylactic Treatment of Very Premature Infants with Human Surfactant
AU - Merritt, T. Allen
AU - Hallman, Mikko
AU - Bloom, Barry T.
AU - Berry, Charles
AU - Benirschke, Kurt
AU - Sahn, David
AU - Key, Thomas
AU - Edwards, David
AU - Jarvenpaa, Anna Liisa
AU - Pohjavuori, Maija
AU - Kankaanpaa, Kaisa
AU - Kunnas, Marjatta
AU - Paatero, Heikki
AU - Rapola, Juhani
AU - Jaaskelainen, Jaakko
PY - 1986/9/25
Y1 - 1986/9/25
N2 - We undertook a randomized, controlled trial to determine whether human surfactant administered endotracheally at birth to very premature infants (gestational age, 24 to 29 weeks) would prevent the respiratory distress syndrome or reduce its severity. Thirty-one treated infants (birth weight, 938±286 g) were compared in a blinded fashion with 29 control infants (birth weight, 964±174 g). The lecithin/sphingomyelin ratio was less than 2 in all infants, and phosphatidylglycerol was not present in amniotic fluid or tracheal fluids at birth, indicating a deficiency of surfactant in the lungs. The principal dependent variables were neonatal death, the incidence of bronchopulmonary dysplasia, and the infant's requirement for respiratory support (and its complications). The surfactant-treated group had significantly fewer deaths than the control group (16 percent vs. 52 percent, P<0.001), fewer cases of bronchopulmonary dysplasia (16 percent vs. 31 percent), and significantly fewer cases of pulmonary interstitial emphysema (P<0.001) and pneumothorax (P<0.02). Prophylactic treatment with human surfactant also substantially reduced the period of neonatal intensive care. We conclude that treatment with human surfactant offers promise for improving the survival of very premature infants with a surfactant deficiency and for reducing the pulmonary sequelae of the respiratory distress syndrome. (N Engl J Med 1986; 315:785–90.), Since the pioneering observation of Avery and Mead1 that surface activity of pulmonary surfactant was decreased in the airways of infants dying of hyaline membrane disease, and the finding by Adams and coworkers2 that airway secretions from such infants were deficient in surface active phospholipids, neonatologists have sought to restore surfactant sufficiency in infants with the respiratory distress syndrome. We have previously demonstrated that human surfactant, administered endotracheally to very-low-birth-weight infants with ventilatory failure caused by severe respiratory distress syndrome, reverses the progressive hypoxemia and improves the arterial–alveolar oxygen-tension ratio while decreasing the mean airway pressure and oxygen requirements.3 Infants….
AB - We undertook a randomized, controlled trial to determine whether human surfactant administered endotracheally at birth to very premature infants (gestational age, 24 to 29 weeks) would prevent the respiratory distress syndrome or reduce its severity. Thirty-one treated infants (birth weight, 938±286 g) were compared in a blinded fashion with 29 control infants (birth weight, 964±174 g). The lecithin/sphingomyelin ratio was less than 2 in all infants, and phosphatidylglycerol was not present in amniotic fluid or tracheal fluids at birth, indicating a deficiency of surfactant in the lungs. The principal dependent variables were neonatal death, the incidence of bronchopulmonary dysplasia, and the infant's requirement for respiratory support (and its complications). The surfactant-treated group had significantly fewer deaths than the control group (16 percent vs. 52 percent, P<0.001), fewer cases of bronchopulmonary dysplasia (16 percent vs. 31 percent), and significantly fewer cases of pulmonary interstitial emphysema (P<0.001) and pneumothorax (P<0.02). Prophylactic treatment with human surfactant also substantially reduced the period of neonatal intensive care. We conclude that treatment with human surfactant offers promise for improving the survival of very premature infants with a surfactant deficiency and for reducing the pulmonary sequelae of the respiratory distress syndrome. (N Engl J Med 1986; 315:785–90.), Since the pioneering observation of Avery and Mead1 that surface activity of pulmonary surfactant was decreased in the airways of infants dying of hyaline membrane disease, and the finding by Adams and coworkers2 that airway secretions from such infants were deficient in surface active phospholipids, neonatologists have sought to restore surfactant sufficiency in infants with the respiratory distress syndrome. We have previously demonstrated that human surfactant, administered endotracheally to very-low-birth-weight infants with ventilatory failure caused by severe respiratory distress syndrome, reverses the progressive hypoxemia and improves the arterial–alveolar oxygen-tension ratio while decreasing the mean airway pressure and oxygen requirements.3 Infants….
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U2 - 10.1056/NEJM198609253151301
DO - 10.1056/NEJM198609253151301
M3 - Article
C2 - 3528853
AN - SCOPUS:0022448523
SN - 0028-4793
VL - 315
SP - 785
EP - 790
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 13
ER -