Prophylactic ibuprofen does not improve pain with IUD insertion: A randomized trial

Paula Bednarek, Mitchell D. Creinin, Matthew F. Reeves, Carrie Cwiak, Eve Espey, Jeffrey Jensen

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective To evaluate if ibuprofen 800 mg reduces pain with intrauterine device (IUD) insertion among U.S. women. Study design We conducted a randomized, double-blind, placebo-controlled trial of women undergoing IUD insertion approximately 2-6 weeks following first-trimester uterine aspiration. Subjects were randomized to receive ibuprofen 800 mg or placebo 30-45 min prior to IUD insertion. A 100-mm visual analog scale (VAS) was administered to measure pain after speculum insertion (baseline) and immediately following IUD insertion. Results A total of 202 women were enrolled, with 101 randomized to each group (ibuprofen or placebo). Sociodemographic characteristics and baseline VAS scores were similar between groups. The median pain score with IUD insertion was 41.5 mm in the placebo group and 38.0 mm in the ibuprofen group (p=.50). Mean and median pain scores did not differ between placebo and ibuprofen when nulliparous and parous women were analyzed independently. Overall, median pain scores were 17.5 mm higher in nulliparous women than parous women (p=.004). Median pain scores did not differ by age, IUD-type, history of dysmenorrhea or time since aspiration. Conclusions Administration of ibuprofen 800 mg prior to IUD insertion does not reduce pain associated with the procedure for U.S. women. Overall, nulliparous women report more pain with IUD insertion than multiparous women.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalContraception
Volume91
Issue number3
DOIs
StatePublished - Mar 1 2015

Fingerprint

Intrauterine Devices
Ibuprofen
Pain
Placebos
Visual Analog Scale
Dysmenorrhea
First Pregnancy Trimester
Surgical Instruments

Keywords

  • Ibuprofen
  • Intrauterine device
  • IUD
  • Pain

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Prophylactic ibuprofen does not improve pain with IUD insertion : A randomized trial. / Bednarek, Paula; Creinin, Mitchell D.; Reeves, Matthew F.; Cwiak, Carrie; Espey, Eve; Jensen, Jeffrey.

In: Contraception, Vol. 91, No. 3, 01.03.2015, p. 193-197.

Research output: Contribution to journalArticle

Bednarek, Paula ; Creinin, Mitchell D. ; Reeves, Matthew F. ; Cwiak, Carrie ; Espey, Eve ; Jensen, Jeffrey. / Prophylactic ibuprofen does not improve pain with IUD insertion : A randomized trial. In: Contraception. 2015 ; Vol. 91, No. 3. pp. 193-197.
@article{e4692fabf34845469eb779f49f40877b,
title = "Prophylactic ibuprofen does not improve pain with IUD insertion: A randomized trial",
abstract = "Objective To evaluate if ibuprofen 800 mg reduces pain with intrauterine device (IUD) insertion among U.S. women. Study design We conducted a randomized, double-blind, placebo-controlled trial of women undergoing IUD insertion approximately 2-6 weeks following first-trimester uterine aspiration. Subjects were randomized to receive ibuprofen 800 mg or placebo 30-45 min prior to IUD insertion. A 100-mm visual analog scale (VAS) was administered to measure pain after speculum insertion (baseline) and immediately following IUD insertion. Results A total of 202 women were enrolled, with 101 randomized to each group (ibuprofen or placebo). Sociodemographic characteristics and baseline VAS scores were similar between groups. The median pain score with IUD insertion was 41.5 mm in the placebo group and 38.0 mm in the ibuprofen group (p=.50). Mean and median pain scores did not differ between placebo and ibuprofen when nulliparous and parous women were analyzed independently. Overall, median pain scores were 17.5 mm higher in nulliparous women than parous women (p=.004). Median pain scores did not differ by age, IUD-type, history of dysmenorrhea or time since aspiration. Conclusions Administration of ibuprofen 800 mg prior to IUD insertion does not reduce pain associated with the procedure for U.S. women. Overall, nulliparous women report more pain with IUD insertion than multiparous women.",
keywords = "Ibuprofen, Intrauterine device, IUD, Pain",
author = "Paula Bednarek and Creinin, {Mitchell D.} and Reeves, {Matthew F.} and Carrie Cwiak and Eve Espey and Jeffrey Jensen",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.contraception.2014.11.012",
language = "English (US)",
volume = "91",
pages = "193--197",
journal = "Contraception",
issn = "0010-7824",
publisher = "Elsevier USA",
number = "3",

}

TY - JOUR

T1 - Prophylactic ibuprofen does not improve pain with IUD insertion

T2 - A randomized trial

AU - Bednarek, Paula

AU - Creinin, Mitchell D.

AU - Reeves, Matthew F.

AU - Cwiak, Carrie

AU - Espey, Eve

AU - Jensen, Jeffrey

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Objective To evaluate if ibuprofen 800 mg reduces pain with intrauterine device (IUD) insertion among U.S. women. Study design We conducted a randomized, double-blind, placebo-controlled trial of women undergoing IUD insertion approximately 2-6 weeks following first-trimester uterine aspiration. Subjects were randomized to receive ibuprofen 800 mg or placebo 30-45 min prior to IUD insertion. A 100-mm visual analog scale (VAS) was administered to measure pain after speculum insertion (baseline) and immediately following IUD insertion. Results A total of 202 women were enrolled, with 101 randomized to each group (ibuprofen or placebo). Sociodemographic characteristics and baseline VAS scores were similar between groups. The median pain score with IUD insertion was 41.5 mm in the placebo group and 38.0 mm in the ibuprofen group (p=.50). Mean and median pain scores did not differ between placebo and ibuprofen when nulliparous and parous women were analyzed independently. Overall, median pain scores were 17.5 mm higher in nulliparous women than parous women (p=.004). Median pain scores did not differ by age, IUD-type, history of dysmenorrhea or time since aspiration. Conclusions Administration of ibuprofen 800 mg prior to IUD insertion does not reduce pain associated with the procedure for U.S. women. Overall, nulliparous women report more pain with IUD insertion than multiparous women.

AB - Objective To evaluate if ibuprofen 800 mg reduces pain with intrauterine device (IUD) insertion among U.S. women. Study design We conducted a randomized, double-blind, placebo-controlled trial of women undergoing IUD insertion approximately 2-6 weeks following first-trimester uterine aspiration. Subjects were randomized to receive ibuprofen 800 mg or placebo 30-45 min prior to IUD insertion. A 100-mm visual analog scale (VAS) was administered to measure pain after speculum insertion (baseline) and immediately following IUD insertion. Results A total of 202 women were enrolled, with 101 randomized to each group (ibuprofen or placebo). Sociodemographic characteristics and baseline VAS scores were similar between groups. The median pain score with IUD insertion was 41.5 mm in the placebo group and 38.0 mm in the ibuprofen group (p=.50). Mean and median pain scores did not differ between placebo and ibuprofen when nulliparous and parous women were analyzed independently. Overall, median pain scores were 17.5 mm higher in nulliparous women than parous women (p=.004). Median pain scores did not differ by age, IUD-type, history of dysmenorrhea or time since aspiration. Conclusions Administration of ibuprofen 800 mg prior to IUD insertion does not reduce pain associated with the procedure for U.S. women. Overall, nulliparous women report more pain with IUD insertion than multiparous women.

KW - Ibuprofen

KW - Intrauterine device

KW - IUD

KW - Pain

UR - http://www.scopus.com/inward/record.url?scp=84923293205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923293205&partnerID=8YFLogxK

U2 - 10.1016/j.contraception.2014.11.012

DO - 10.1016/j.contraception.2014.11.012

M3 - Article

C2 - 25487172

AN - SCOPUS:84923293205

VL - 91

SP - 193

EP - 197

JO - Contraception

JF - Contraception

SN - 0010-7824

IS - 3

ER -