Proopiomelanocortin messenger RNA is decreased in the mediobasal hypothalamus of rats made dependent on ethanol

M. N. Scanlon, E. Lazar-Wesley, Kathleen (Kathy) Grant, G. Kunos

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

It is thought that certain actions of ethanol involve an interaction with endogenous opioids, including proopiomelanocortin-derived peptides such as β-endorphin. To examine this possibility, we used a sensitive and specific assay for proopiomelanocortin mRNA to obtain an estimate of the activity of the endorphinergic system in the mediobasal hypothalamus and the pituitary of rats exposed for 10 days in an inhalation chamber to either ethanol or water. This protocol causes dependence in the ethanol-exposed group, as demonstrated by the presence of withdrawal seizures after cessation of treatment. While ethanol treatment did not affect proopiomelanocortin mRNA levels in the pituitary, the level in hypothalamus was significantly lower in the ethanol- treated animals than in controls. These results suggest that some effects of ethanol may involve the hypothalamic endorphinergic system.

Original languageEnglish (US)
Pages (from-to)1147-1151
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume16
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Pro-Opiomelanocortin
Hypothalamus
Rats
Ethanol
Messenger RNA
Endorphins
Withholding Treatment
Inhalation
Opioid Analgesics
Assays
Animals
Seizures
Peptides
Water

Keywords

  • Ethanol
  • Hypothalamus
  • Proopiomelanocortin
  • Rat

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology

Cite this

Proopiomelanocortin messenger RNA is decreased in the mediobasal hypothalamus of rats made dependent on ethanol. / Scanlon, M. N.; Lazar-Wesley, E.; Grant, Kathleen (Kathy); Kunos, G.

In: Alcoholism: Clinical and Experimental Research, Vol. 16, No. 6, 1992, p. 1147-1151.

Research output: Contribution to journalArticle

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