Prolonged tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death

Ragesh Panikkath, Kyndaron Reinier, Audrey Uy-Evanado, Carmen Teodorescu, Jonathan Hattenhauer, Ronald Mariani, Karen Gunson, Jonathan Jui, Sumeet S. Chugh

Research output: Contribution to journalArticle

205 Citations (Scopus)

Abstract

Background-Early studies indicate that prolongation of the interval between the peak and the end of the T wave (Tpeak to Tend [TpTe]) on the 12-lead ECG is a marker of ventricular arrhythmogenesis. However, community-based studies have not been conducted. Methods and Results-TpTe and other ECG predictors were evaluated in the ongoing Oregon Sudden Unexpected Death Study based in the Portland, Oregon, metropolitan area using a case-control design. Cases of sudden cardiac death (SCD) (n=353; mean age, 66.6 years; 95% CI, 65.1 to 68.1 years; 67% men) were compared with living controls with coronary artery disease (n=342; mean age, 64.7 years; 95% CI, 63.4 to 66.0 years; 69% men) from the same region. Analysis of TpTe and selected ECG intervals was limited to sinus rhythm 12-lead ECGs. For cases, these were obtained before and unrelated to SCD. Independent-samples t tests and multiple logistic regression were used. Mean TpTe was significantly greater in cases (89.4 ms; 95% CI, 87.7 to 91.2 ms; P

Original languageEnglish (US)
Pages (from-to)441-447
Number of pages7
JournalCirculation: Arrhythmia and Electrophysiology
Volume4
Issue number4
DOIs
StatePublished - Aug 2011

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Sudden Cardiac Death
Electrocardiography
Sudden Death
Coronary Artery Disease
Logistic Models
Lead

Keywords

  • Coronary disease
  • Death sudden
  • Electrocardiography
  • Population
  • Risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Medicine(all)

Cite this

Panikkath, R., Reinier, K., Uy-Evanado, A., Teodorescu, C., Hattenhauer, J., Mariani, R., ... Chugh, S. S. (2011). Prolonged tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circulation: Arrhythmia and Electrophysiology, 4(4), 441-447. https://doi.org/10.1161/CIRCEP.110.960658

Prolonged tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. / Panikkath, Ragesh; Reinier, Kyndaron; Uy-Evanado, Audrey; Teodorescu, Carmen; Hattenhauer, Jonathan; Mariani, Ronald; Gunson, Karen; Jui, Jonathan; Chugh, Sumeet S.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 4, No. 4, 08.2011, p. 441-447.

Research output: Contribution to journalArticle

Panikkath, R, Reinier, K, Uy-Evanado, A, Teodorescu, C, Hattenhauer, J, Mariani, R, Gunson, K, Jui, J & Chugh, SS 2011, 'Prolonged tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death', Circulation: Arrhythmia and Electrophysiology, vol. 4, no. 4, pp. 441-447. https://doi.org/10.1161/CIRCEP.110.960658
Panikkath, Ragesh ; Reinier, Kyndaron ; Uy-Evanado, Audrey ; Teodorescu, Carmen ; Hattenhauer, Jonathan ; Mariani, Ronald ; Gunson, Karen ; Jui, Jonathan ; Chugh, Sumeet S. / Prolonged tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. In: Circulation: Arrhythmia and Electrophysiology. 2011 ; Vol. 4, No. 4. pp. 441-447.
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