Prolonged interval high-dose intravenous immunoglobulin in patients with primary immunodeficiency states

Anthony Montanaro, Bernard Pirofsky

Research output: Contribution to journalArticle

40 Scopus citations


Intravenous immunoglobulin can be a very effective form of treatment for patients with primary immunodeficiency states. Recommendations for intravenous dosing previously have been empirically derived. In order to determine the potential prolongation of intervals between infusions following the administration of 500 mg/kg of intravenous immunoglobulin, 11 patients were studied. This high-dose therapy was well tolerated and resulted in a modest prolongation of therapeutic IgG levels when compared with lower-dose 150 mg/kg regimens. Significant variability among individual patients was observed. Implications of this high-dose therapy are discussed.

Original languageEnglish (US)
Pages (from-to)67-72
Number of pages6
JournalThe American Journal of Medicine
Issue number3 PART 1
StatePublished - Mar 30 1984


ASJC Scopus subject areas

  • Medicine(all)

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