Prolifération gliale rétinienne et acides aminés excitateurs.

Translated title of the contribution: Proliferation of retinal glia and excitatory amino acids

J. A. Sahel, Daniel Albert, S. Lessell

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Kainic acid administered intravitreally induced mitogenic effects in the adult rat retina at doses ranging from 60 nm to 200 nm. Similar effects resulted from the injection of domoic acid at doses ranging from 20 nm to 400 nm, and ouabain. L-glutamate, N-methyl D-aspartate and quisqualate provoked similar cytotoxic effects, i.e., swelling and vasuolization of the outer plexiform, inner nuclear and inner plexiform layer, and cell pycnosis. The latter induced no mitoses. The use of Rompun ketamine as anesthetic blocked the mitogenic effects. The immunohistochemical labelling of both glial fibrillary acidic protein and S100 protein in the dividing cells and the location of dividing nuclei in the inner nuclear layer are arguments for their Müllerian nature. We suggest that the mitogenic effects could account for reactive gliosis observed in some clinical conditions.

Original languageFrench
Pages (from-to)13-16
Number of pages4
JournalOphtalmologie : organe de la Société française d'ophtalmologie
Volume4
Issue number1
Publication statusPublished - Jan 1 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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