Abstract
Prolactin receptors have been identified for the first time on human peripheral blood lymphocytes. These receptors are present on T- and B-cells as well as monocytes. The specific binding of [125I]prolactin to these cells can be selectively enhanced at certain concentrations and blocked by higher concentrations of cyclosporine, a known immunosuppressive agent which inhibits the mitogenesis of T-cells. Prolactin also induces ornithine decarboxylase, a key growth regulatory enzyme, in lymphocytes. Therefore, we suggest that the lymphocyte prolactin receptor may be involved in regulating lymphocyte function, and that one of the actions of cyclosporine is to block this rather ubiquitously occurring receptor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 899-906 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 121 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 29 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
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Prolactin receptors on human lymphocytes and their modulation by cyclosporine. / Russell, Diane Haddock; Matrisian, Lynn; Kibler, Ruthann; Larson, Douglas F.; Poulos, Bonnie; Magun, Bruce E.
In: Biochemical and Biophysical Research Communications, Vol. 121, No. 3, 29.06.1984, p. 899-906.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prolactin receptors on human lymphocytes and their modulation by cyclosporine
AU - Russell, Diane Haddock
AU - Matrisian, Lynn
AU - Kibler, Ruthann
AU - Larson, Douglas F.
AU - Poulos, Bonnie
AU - Magun, Bruce E.
PY - 1984/6/29
Y1 - 1984/6/29
N2 - Prolactin receptors have been identified for the first time on human peripheral blood lymphocytes. These receptors are present on T- and B-cells as well as monocytes. The specific binding of [125I]prolactin to these cells can be selectively enhanced at certain concentrations and blocked by higher concentrations of cyclosporine, a known immunosuppressive agent which inhibits the mitogenesis of T-cells. Prolactin also induces ornithine decarboxylase, a key growth regulatory enzyme, in lymphocytes. Therefore, we suggest that the lymphocyte prolactin receptor may be involved in regulating lymphocyte function, and that one of the actions of cyclosporine is to block this rather ubiquitously occurring receptor.
AB - Prolactin receptors have been identified for the first time on human peripheral blood lymphocytes. These receptors are present on T- and B-cells as well as monocytes. The specific binding of [125I]prolactin to these cells can be selectively enhanced at certain concentrations and blocked by higher concentrations of cyclosporine, a known immunosuppressive agent which inhibits the mitogenesis of T-cells. Prolactin also induces ornithine decarboxylase, a key growth regulatory enzyme, in lymphocytes. Therefore, we suggest that the lymphocyte prolactin receptor may be involved in regulating lymphocyte function, and that one of the actions of cyclosporine is to block this rather ubiquitously occurring receptor.
UR - http://www.scopus.com/inward/record.url?scp=0021243694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021243694&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(84)90762-9
DO - 10.1016/0006-291X(84)90762-9
M3 - Article
C2 - 6331435
AN - SCOPUS:0021243694
VL - 121
SP - 899
EP - 906
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -