Prolactin receptors on human lymphocytes and their modulation by cyclosporine

Diane Haddock Russell; Lynn Matrisian; Ruthann Kibler; Douglas F. Larson; Bonnie Poulos; Bruce E. Magun

doi:10.1016/0006-291X(84)90762-9

Prolactin receptors on human lymphocytes and their modulation by cyclosporine

Diane Haddock Russell, Lynn Matrisian, Ruthann Kibler, Douglas F. Larson, Bonnie Poulos, Bruce E. Magun

Cell, Developmental, & Cancer Biology

Research output: Contribution to journal › Article

149 Scopus citations

Abstract

Prolactin receptors have been identified for the first time on human peripheral blood lymphocytes. These receptors are present on T- and B-cells as well as monocytes. The specific binding of [¹²⁵I]prolactin to these cells can be selectively enhanced at certain concentrations and blocked by higher concentrations of cyclosporine, a known immunosuppressive agent which inhibits the mitogenesis of T-cells. Prolactin also induces ornithine decarboxylase, a key growth regulatory enzyme, in lymphocytes. Therefore, we suggest that the lymphocyte prolactin receptor may be involved in regulating lymphocyte function, and that one of the actions of cyclosporine is to block this rather ubiquitously occurring receptor.

Original language	English (US)
Pages (from-to)	899-906
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	121
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(84)90762-9
State	Published - Jun 29 1984

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Russell, D. H., Matrisian, L., Kibler, R., Larson, D. F., Poulos, B., & Magun, B. E. (1984). Prolactin receptors on human lymphocytes and their modulation by cyclosporine. Biochemical and Biophysical Research Communications, 121(3), 899-906. https://doi.org/10.1016/0006-291X(84)90762-9

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AU - Magun, Bruce E.

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AB - Prolactin receptors have been identified for the first time on human peripheral blood lymphocytes. These receptors are present on T- and B-cells as well as monocytes. The specific binding of [125I]prolactin to these cells can be selectively enhanced at certain concentrations and blocked by higher concentrations of cyclosporine, a known immunosuppressive agent which inhibits the mitogenesis of T-cells. Prolactin also induces ornithine decarboxylase, a key growth regulatory enzyme, in lymphocytes. Therefore, we suggest that the lymphocyte prolactin receptor may be involved in regulating lymphocyte function, and that one of the actions of cyclosporine is to block this rather ubiquitously occurring receptor.

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