Proinflammatory endothelial activation detected by molecular imaging in obese nonhuman primates coincides with onset of insulin resistance and progressively increases with duration of insulin resistance

Scott Chadderdon, J. Todd Belcik, Lindsay Bader, Melissa A. Kirigiti, Dawn Peters, Paul Kievit, Kevin Grove, Jonathan Lindner

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

BACKGROUND - : Inflammation and insulin resistance (IR) are associated processes that potentiate risk for cardiovascular disease in obesity. The temporal relation between IR and inflammation is not completely characterized. We hypothesized that endothelial cell adhesion molecule expression in large arteries is an early event that coincides with diet-induced obesity and IR in primates. METHODS AND RESULTS - : Ten adult male rhesus macaques were studied at baseline and every 4 to 6 months on a high-fat diet for 2 years. Truncal fat, carotid intima-media thickness, plasma inflammatory biomarkers, and carotid P-selectin and vascular cell adhesion molecule-1 expression by contrast-enhanced ultrasound molecular imaging were assessed. Intravenous glucose tolerance test was performed at baseline and at 4 and 18 months. A high-fat diet produced a rapid increase (P

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
JournalCirculation
Volume129
Issue number4
DOIs
StatePublished - Jan 28 2014

Fingerprint

Molecular Imaging
Primates
Insulin Resistance
High Fat Diet
Obesity
Inflammation
Carotid Intima-Media Thickness
P-Selectin
Vascular Cell Adhesion Molecule-1
Cell Adhesion Molecules
Glucose Tolerance Test
Macaca mulatta
Ultrasonography
Cardiovascular Diseases
Endothelial Cells
Arteries
Biomarkers
Fats
Diet

Keywords

  • Endothelium
  • Inflammation
  • Insulin resistance
  • Molecular imaging
  • Obesity

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

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T1 - Proinflammatory endothelial activation detected by molecular imaging in obese nonhuman primates coincides with onset of insulin resistance and progressively increases with duration of insulin resistance

AU - Chadderdon, Scott

AU - Belcik, J. Todd

AU - Bader, Lindsay

AU - Kirigiti, Melissa A.

AU - Peters, Dawn

AU - Kievit, Paul

AU - Grove, Kevin

AU - Lindner, Jonathan

PY - 2014/1/28

Y1 - 2014/1/28

N2 - BACKGROUND - : Inflammation and insulin resistance (IR) are associated processes that potentiate risk for cardiovascular disease in obesity. The temporal relation between IR and inflammation is not completely characterized. We hypothesized that endothelial cell adhesion molecule expression in large arteries is an early event that coincides with diet-induced obesity and IR in primates. METHODS AND RESULTS - : Ten adult male rhesus macaques were studied at baseline and every 4 to 6 months on a high-fat diet for 2 years. Truncal fat, carotid intima-media thickness, plasma inflammatory biomarkers, and carotid P-selectin and vascular cell adhesion molecule-1 expression by contrast-enhanced ultrasound molecular imaging were assessed. Intravenous glucose tolerance test was performed at baseline and at 4 and 18 months. A high-fat diet produced a rapid increase (P

AB - BACKGROUND - : Inflammation and insulin resistance (IR) are associated processes that potentiate risk for cardiovascular disease in obesity. The temporal relation between IR and inflammation is not completely characterized. We hypothesized that endothelial cell adhesion molecule expression in large arteries is an early event that coincides with diet-induced obesity and IR in primates. METHODS AND RESULTS - : Ten adult male rhesus macaques were studied at baseline and every 4 to 6 months on a high-fat diet for 2 years. Truncal fat, carotid intima-media thickness, plasma inflammatory biomarkers, and carotid P-selectin and vascular cell adhesion molecule-1 expression by contrast-enhanced ultrasound molecular imaging were assessed. Intravenous glucose tolerance test was performed at baseline and at 4 and 18 months. A high-fat diet produced a rapid increase (P

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