Progress and perspectives in plant sterol and plant stanol research

Peter J.H. Jones, Maryam Shamloo, Dylan S. MacKay, Todd C. Rideout, Semone B. Myrie, Jogchum Plat, Jean-Baptiste Roullet, David J. Baer, Kara L. Calkins, Harry R. Davis, Paul Duell, Henry Ginsberg, Helena Gylling, David Jenkins, Dieter Lütjohann, Mohammad Moghadasian, Robert A. Moreau, David Mymin, Richard E. Ostlund, Rouyanne T. RasJavier Ochoa Reparaz, Elke A. Trautwein, Stephen Turley, Tim Vanmierlo, Oliver Weingärtner

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

Original languageEnglish (US)
Pages (from-to)725-746
Number of pages22
JournalNutrition Reviews
Volume76
Issue number10
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Cholesterol
  • Nutrition
  • Plant stanols
  • Plant sterols
  • Sitosterolemia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Jones, P. J. H., Shamloo, M., MacKay, D. S., Rideout, T. C., Myrie, S. B., Plat, J., Roullet, J-B., Baer, D. J., Calkins, K. L., Davis, H. R., Duell, P., Ginsberg, H., Gylling, H., Jenkins, D., Lütjohann, D., Moghadasian, M., Moreau, R. A., Mymin, D., Ostlund, R. E., ... Weingärtner, O. (2018). Progress and perspectives in plant sterol and plant stanol research. Nutrition Reviews, 76(10), 725-746. https://doi.org/10.1093/nutrit/nuy032