Programmable cell adhesion encoded by DNA hybridization

Ravi A. Chandra, Erik S. Douglas, Richard A. Mathies, Carolyn R. Bertozzi, Matthew B. Francis

Research output: Contribution to journalArticlepeer-review

123 Scopus citations

Abstract

(Figure Presented) Stuck-on genes: Live cells functionalized with single-stranded DNA oligonucleotides bind, independent of native adhesion mechanisms, to substrates that bear complementary DNA strands in a sequence-specific manner. This strategy has been successfully utilized with several common mammalian cell lines and device platforms.

Original languageEnglish (US)
Pages (from-to)896-901
Number of pages6
JournalAngewandte Chemie - International Edition
Volume45
Issue number6
DOIs
StatePublished - Jan 30 2006
Externally publishedYes

Keywords

  • Cell adhesion
  • Chemical biology
  • DNA recognition
  • Glycoproteins
  • Staudinger ligation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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