Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia

Hiroyuki Nakai, S. Misawa, M. Taniwaki, S. Horiike, T. Takashima, T. Seriu, H. Nakagawa, H. Fujii, C. Shimazaki, N. Maruo, T. Akaogi, N. Uike, T. Abe, K. Kashima

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In 31 cases of chronic myelogenous leukaemia (CML) we examined the prognostic significance of chromosomal loss of a 17p and p53 mutations at the onset of blast crisis (BC). p53 mutations were closely related to a shortened survival in CML-BC (P <0.005 by the logrank test), whereas loss of a 17p by itself was not a poor prognostic indicator. The prognostic significance of loss of a 17p, however, emerged when combined with its predominance in the metaphases analysed. This predominance might easily and rapidly be screened by polymerase chain reaction-based analysis in about half of the cases.

Original languageEnglish (US)
Pages (from-to)425-427
Number of pages3
JournalBritish Journal of Haematology
Volume87
Issue number2
StatePublished - 1994
Externally publishedYes

Fingerprint

Blast Crisis
p53 Genes
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chromosomes
Mutation
Metaphase
Polymerase Chain Reaction

Keywords

  • Blast crisis
  • Chromosome 17
  • CML
  • p53
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Nakai, H., Misawa, S., Taniwaki, M., Horiike, S., Takashima, T., Seriu, T., ... Kashima, K. (1994). Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia. British Journal of Haematology, 87(2), 425-427.

Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia. / Nakai, Hiroyuki; Misawa, S.; Taniwaki, M.; Horiike, S.; Takashima, T.; Seriu, T.; Nakagawa, H.; Fujii, H.; Shimazaki, C.; Maruo, N.; Akaogi, T.; Uike, N.; Abe, T.; Kashima, K.

In: British Journal of Haematology, Vol. 87, No. 2, 1994, p. 425-427.

Research output: Contribution to journalArticle

Nakai, H, Misawa, S, Taniwaki, M, Horiike, S, Takashima, T, Seriu, T, Nakagawa, H, Fujii, H, Shimazaki, C, Maruo, N, Akaogi, T, Uike, N, Abe, T & Kashima, K 1994, 'Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia', British Journal of Haematology, vol. 87, no. 2, pp. 425-427.
Nakai, Hiroyuki ; Misawa, S. ; Taniwaki, M. ; Horiike, S. ; Takashima, T. ; Seriu, T. ; Nakagawa, H. ; Fujii, H. ; Shimazaki, C. ; Maruo, N. ; Akaogi, T. ; Uike, N. ; Abe, T. ; Kashima, K. / Prognostic significance of loss of a chromosome 17p and p53 gene mutations in blast crisis of chronic myelogenous leukaemia. In: British Journal of Haematology. 1994 ; Vol. 87, No. 2. pp. 425-427.
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