Prognostic factors and immunobiologic insights into Merkel cell carcinoma

Dale Han, Jayasri G. Iyer

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Merkel cell carcinoma is an aggressive cutaneous neuroendocrine cancer, and although the current staging system takes into account several prognostic features, further study is needed to better determine whether other clinicopathologic features are also predictive of survival. The discovery of the Merkel cell polyomavirus with persistently expressed viral epitopes and an understanding of the various immune evasion mechanisms in Merkel cell carcinoma tumors provide an exciting and unique opportunity for the development of rational immune therapies to improve patient outcomes for this biologically unique, virus-associated cancer.

Original languageEnglish (US)
Pages (from-to)3193-3196
Number of pages4
JournalCancer
Volume121
Issue number18
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

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Merkel Cell Carcinoma
Merkel cell polyomavirus
Immune Evasion
Skin Neoplasms
Epitopes
Viruses
Survival
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Prognostic factors and immunobiologic insights into Merkel cell carcinoma. / Han, Dale; Iyer, Jayasri G.

In: Cancer, Vol. 121, No. 18, 01.09.2015, p. 3193-3196.

Research output: Contribution to journalReview article

Han, Dale ; Iyer, Jayasri G. / Prognostic factors and immunobiologic insights into Merkel cell carcinoma. In: Cancer. 2015 ; Vol. 121, No. 18. pp. 3193-3196.
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