Prognosis of women with stage I endometrioid endometrial cancer and synchronous stage I endometrioid ovarian cancer

Koji Matsuo, Hiroko Machida, Marina Frimer, Jenna Z. Marcus, Tanja Pejovic, Lynda D. Roman, Jason D. Wright

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: Synchronous endometrial and ovarian cancer with endometrioid histology at two cancer sites typically presents with early-stage disease and is thought to have a good prognosis. We examined the survival of women with early-stage endometrioid endometrial cancer who had synchronous early-stage endometrioid ovarian cancer. Methods: This is a retrospective case-control study examining the Surveillance, Epidemiology, and End Result Program between 1973 and 2013. Survival of women with stage I endometrioid endometrial cancer with stage I endometrioid ovarian cancer (n = 839) were compared to women with stage I endometrioid endometrial cancer without synchronous ovarian cancer (n = 123,692) after propensity score matching. Results: Women with synchronous stage I endometrioid ovarian cancer were more likely to be diagnosed recently, be younger, have stage IA disease, grade 1 tumors, to have undergone lymphadenectomy, and were less likely to receive radiotherapy compared to those without synchronous ovarian cancer (all, P <. 0.001). In a propensity score matched model, the presence of synchronous ovarian cancer was not associated with endometrial cancer-specific survival (10-year rates 96.0% versus 95.3%, P = 0.97) or overall survival (85.6% versus 87.2%, P = 0.10). Among tumors with concordant grades at the two cancer sites, survival was similar regardless of presence of synchronous ovarian tumors (grade 1 tumors, 10-year rate for overall survival, 88.2% versus 89.1%, P = 0.40; and grade 2 tumors, 84.0% versus 85.8%, P = 0.78). Conclusion: Women with stage I endometrioid endometrial cancer with synchronous stage I endometrioid ovarian cancer have a survival outcome similar to those with stage I endometrioid endometrial cancer without synchronous ovarian cancer.

Original languageEnglish (US)
JournalGynecologic Oncology
DOIs
StateAccepted/In press - 2017

Fingerprint

Endometrial Neoplasms
Ovarian Neoplasms
Survival
Neoplasms
Propensity Score
SEER Program
Lymph Node Excision
Case-Control Studies
Histology
Radiotherapy
Survival Rate

Keywords

  • Endometrial cancer
  • Ovarian cancer
  • Prognosis
  • Synchronous

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Prognosis of women with stage I endometrioid endometrial cancer and synchronous stage I endometrioid ovarian cancer. / Matsuo, Koji; Machida, Hiroko; Frimer, Marina; Marcus, Jenna Z.; Pejovic, Tanja; Roman, Lynda D.; Wright, Jason D.

In: Gynecologic Oncology, 2017.

Research output: Contribution to journalArticle

Matsuo, Koji ; Machida, Hiroko ; Frimer, Marina ; Marcus, Jenna Z. ; Pejovic, Tanja ; Roman, Lynda D. ; Wright, Jason D. / Prognosis of women with stage I endometrioid endometrial cancer and synchronous stage I endometrioid ovarian cancer. In: Gynecologic Oncology. 2017.
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title = "Prognosis of women with stage I endometrioid endometrial cancer and synchronous stage I endometrioid ovarian cancer",
abstract = "Objective: Synchronous endometrial and ovarian cancer with endometrioid histology at two cancer sites typically presents with early-stage disease and is thought to have a good prognosis. We examined the survival of women with early-stage endometrioid endometrial cancer who had synchronous early-stage endometrioid ovarian cancer. Methods: This is a retrospective case-control study examining the Surveillance, Epidemiology, and End Result Program between 1973 and 2013. Survival of women with stage I endometrioid endometrial cancer with stage I endometrioid ovarian cancer (n = 839) were compared to women with stage I endometrioid endometrial cancer without synchronous ovarian cancer (n = 123,692) after propensity score matching. Results: Women with synchronous stage I endometrioid ovarian cancer were more likely to be diagnosed recently, be younger, have stage IA disease, grade 1 tumors, to have undergone lymphadenectomy, and were less likely to receive radiotherapy compared to those without synchronous ovarian cancer (all, P <. 0.001). In a propensity score matched model, the presence of synchronous ovarian cancer was not associated with endometrial cancer-specific survival (10-year rates 96.0{\%} versus 95.3{\%}, P = 0.97) or overall survival (85.6{\%} versus 87.2{\%}, P = 0.10). Among tumors with concordant grades at the two cancer sites, survival was similar regardless of presence of synchronous ovarian tumors (grade 1 tumors, 10-year rate for overall survival, 88.2{\%} versus 89.1{\%}, P = 0.40; and grade 2 tumors, 84.0{\%} versus 85.8{\%}, P = 0.78). Conclusion: Women with stage I endometrioid endometrial cancer with synchronous stage I endometrioid ovarian cancer have a survival outcome similar to those with stage I endometrioid endometrial cancer without synchronous ovarian cancer.",
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T1 - Prognosis of women with stage I endometrioid endometrial cancer and synchronous stage I endometrioid ovarian cancer

AU - Matsuo, Koji

AU - Machida, Hiroko

AU - Frimer, Marina

AU - Marcus, Jenna Z.

AU - Pejovic, Tanja

AU - Roman, Lynda D.

AU - Wright, Jason D.

PY - 2017

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N2 - Objective: Synchronous endometrial and ovarian cancer with endometrioid histology at two cancer sites typically presents with early-stage disease and is thought to have a good prognosis. We examined the survival of women with early-stage endometrioid endometrial cancer who had synchronous early-stage endometrioid ovarian cancer. Methods: This is a retrospective case-control study examining the Surveillance, Epidemiology, and End Result Program between 1973 and 2013. Survival of women with stage I endometrioid endometrial cancer with stage I endometrioid ovarian cancer (n = 839) were compared to women with stage I endometrioid endometrial cancer without synchronous ovarian cancer (n = 123,692) after propensity score matching. Results: Women with synchronous stage I endometrioid ovarian cancer were more likely to be diagnosed recently, be younger, have stage IA disease, grade 1 tumors, to have undergone lymphadenectomy, and were less likely to receive radiotherapy compared to those without synchronous ovarian cancer (all, P <. 0.001). In a propensity score matched model, the presence of synchronous ovarian cancer was not associated with endometrial cancer-specific survival (10-year rates 96.0% versus 95.3%, P = 0.97) or overall survival (85.6% versus 87.2%, P = 0.10). Among tumors with concordant grades at the two cancer sites, survival was similar regardless of presence of synchronous ovarian tumors (grade 1 tumors, 10-year rate for overall survival, 88.2% versus 89.1%, P = 0.40; and grade 2 tumors, 84.0% versus 85.8%, P = 0.78). Conclusion: Women with stage I endometrioid endometrial cancer with synchronous stage I endometrioid ovarian cancer have a survival outcome similar to those with stage I endometrioid endometrial cancer without synchronous ovarian cancer.

AB - Objective: Synchronous endometrial and ovarian cancer with endometrioid histology at two cancer sites typically presents with early-stage disease and is thought to have a good prognosis. We examined the survival of women with early-stage endometrioid endometrial cancer who had synchronous early-stage endometrioid ovarian cancer. Methods: This is a retrospective case-control study examining the Surveillance, Epidemiology, and End Result Program between 1973 and 2013. Survival of women with stage I endometrioid endometrial cancer with stage I endometrioid ovarian cancer (n = 839) were compared to women with stage I endometrioid endometrial cancer without synchronous ovarian cancer (n = 123,692) after propensity score matching. Results: Women with synchronous stage I endometrioid ovarian cancer were more likely to be diagnosed recently, be younger, have stage IA disease, grade 1 tumors, to have undergone lymphadenectomy, and were less likely to receive radiotherapy compared to those without synchronous ovarian cancer (all, P <. 0.001). In a propensity score matched model, the presence of synchronous ovarian cancer was not associated with endometrial cancer-specific survival (10-year rates 96.0% versus 95.3%, P = 0.97) or overall survival (85.6% versus 87.2%, P = 0.10). Among tumors with concordant grades at the two cancer sites, survival was similar regardless of presence of synchronous ovarian tumors (grade 1 tumors, 10-year rate for overall survival, 88.2% versus 89.1%, P = 0.40; and grade 2 tumors, 84.0% versus 85.8%, P = 0.78). Conclusion: Women with stage I endometrioid endometrial cancer with synchronous stage I endometrioid ovarian cancer have a survival outcome similar to those with stage I endometrioid endometrial cancer without synchronous ovarian cancer.

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KW - Ovarian cancer

KW - Prognosis

KW - Synchronous

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