Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis

M. A. Yates, Y. Li, P. Chlebeck, T. Proctor, A. A. Vandenbark, H. Offner

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Ovarian hormones, including progesterone, are known to have immunomodulatory and neuroprotective effects which may alter the disease course of experimental autoimmune encephalomyelitis (EAE). In the current study, we examined the treatment potential of progesterone beginning at the onset of EAE symptoms. Progesterone treated animals showed reduced peak disease scores and cumulative disease indices, and decreased inflammatory cytokine secretion (IL-2 and IL-17). In addition, increased production of IL-10 was accompanied by increased numbers of CD19+ cells and an increase in CD8+ cells. Decreased chemokine and chemokine receptor expression in the spinal cord also contributed to decreased lesions in the spinal cord.

Original languageEnglish (US)
Pages (from-to)136-139
Number of pages4
JournalJournal of Neuroimmunology
Volume220
Issue number1-2
DOIs
StatePublished - Mar 30 2010

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Keywords

  • B cells
  • EAE
  • Estrogen
  • Multiple sclerosis
  • Progesterone

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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