Profile of immunologic recovery in HIV-infected Ugandan adults after antiretroviral therapy

Chris A R Baker, Nneka Emenyonu, Isaac Ssewanyana, Norman G. Jones, Mohamed Elrefaei, Frehd Nghania, Justine Nakiwala, Irene Andia, Richard Clark, Jeffrey Martin, David Bangsberg, Huyen Cao

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

HIV infection is characterized by a decrease in total CD4 cell count, rising viral load, as well as an increase in immune activation levels. Increased activation can lead to an increase in apoptosis and contribute to CD4 depletion. We evaluated the clinical and immunologic responses of 23 HIV-positive Ugandan volunteers following initiation of antiretroviral therapy (ART). All volunteers achieved and maintained complete viral suppression within the first 3 months of therapy (p > 0.05). CD4 + and CD8 + T cell activation also decreased significantly, although it never reached the level of HIV negative Ugandan volunteers. Viral suppression and CD4 cell recovery were also associated with an improved profile in CD8 + T cell functional markers, but had no effect on HIV-specific proliferation. We conclude that ART in a cohort of therapy-naive Ugandans with AIDS partially restores but does not fully reverse the immune dysfunction observed in chronic HIV infection.

Original languageEnglish (US)
Pages (from-to)900-905
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume23
Issue number7
DOIs
StatePublished - Jul 2007
Externally publishedYes

Fingerprint

HIV
Volunteers
HIV Infections
T-Lymphocytes
Therapeutics
CD4 Lymphocyte Count
Viral Load
Acquired Immunodeficiency Syndrome
Apoptosis

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Baker, C. A. R., Emenyonu, N., Ssewanyana, I., Jones, N. G., Elrefaei, M., Nghania, F., ... Cao, H. (2007). Profile of immunologic recovery in HIV-infected Ugandan adults after antiretroviral therapy. AIDS Research and Human Retroviruses, 23(7), 900-905. https://doi.org/10.1089/aid.2006.0309

Profile of immunologic recovery in HIV-infected Ugandan adults after antiretroviral therapy. / Baker, Chris A R; Emenyonu, Nneka; Ssewanyana, Isaac; Jones, Norman G.; Elrefaei, Mohamed; Nghania, Frehd; Nakiwala, Justine; Andia, Irene; Clark, Richard; Martin, Jeffrey; Bangsberg, David; Cao, Huyen.

In: AIDS Research and Human Retroviruses, Vol. 23, No. 7, 07.2007, p. 900-905.

Research output: Contribution to journalArticle

Baker, CAR, Emenyonu, N, Ssewanyana, I, Jones, NG, Elrefaei, M, Nghania, F, Nakiwala, J, Andia, I, Clark, R, Martin, J, Bangsberg, D & Cao, H 2007, 'Profile of immunologic recovery in HIV-infected Ugandan adults after antiretroviral therapy', AIDS Research and Human Retroviruses, vol. 23, no. 7, pp. 900-905. https://doi.org/10.1089/aid.2006.0309
Baker, Chris A R ; Emenyonu, Nneka ; Ssewanyana, Isaac ; Jones, Norman G. ; Elrefaei, Mohamed ; Nghania, Frehd ; Nakiwala, Justine ; Andia, Irene ; Clark, Richard ; Martin, Jeffrey ; Bangsberg, David ; Cao, Huyen. / Profile of immunologic recovery in HIV-infected Ugandan adults after antiretroviral therapy. In: AIDS Research and Human Retroviruses. 2007 ; Vol. 23, No. 7. pp. 900-905.
@article{b668905512544e3fa4309b2cc9968894,
title = "Profile of immunologic recovery in HIV-infected Ugandan adults after antiretroviral therapy",
abstract = "HIV infection is characterized by a decrease in total CD4 cell count, rising viral load, as well as an increase in immune activation levels. Increased activation can lead to an increase in apoptosis and contribute to CD4 depletion. We evaluated the clinical and immunologic responses of 23 HIV-positive Ugandan volunteers following initiation of antiretroviral therapy (ART). All volunteers achieved and maintained complete viral suppression within the first 3 months of therapy (p > 0.05). CD4 + and CD8 + T cell activation also decreased significantly, although it never reached the level of HIV negative Ugandan volunteers. Viral suppression and CD4 cell recovery were also associated with an improved profile in CD8 + T cell functional markers, but had no effect on HIV-specific proliferation. We conclude that ART in a cohort of therapy-naive Ugandans with AIDS partially restores but does not fully reverse the immune dysfunction observed in chronic HIV infection.",
author = "Baker, {Chris A R} and Nneka Emenyonu and Isaac Ssewanyana and Jones, {Norman G.} and Mohamed Elrefaei and Frehd Nghania and Justine Nakiwala and Irene Andia and Richard Clark and Jeffrey Martin and David Bangsberg and Huyen Cao",
year = "2007",
month = "7",
doi = "10.1089/aid.2006.0309",
language = "English (US)",
volume = "23",
pages = "900--905",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

TY - JOUR

T1 - Profile of immunologic recovery in HIV-infected Ugandan adults after antiretroviral therapy

AU - Baker, Chris A R

AU - Emenyonu, Nneka

AU - Ssewanyana, Isaac

AU - Jones, Norman G.

AU - Elrefaei, Mohamed

AU - Nghania, Frehd

AU - Nakiwala, Justine

AU - Andia, Irene

AU - Clark, Richard

AU - Martin, Jeffrey

AU - Bangsberg, David

AU - Cao, Huyen

PY - 2007/7

Y1 - 2007/7

N2 - HIV infection is characterized by a decrease in total CD4 cell count, rising viral load, as well as an increase in immune activation levels. Increased activation can lead to an increase in apoptosis and contribute to CD4 depletion. We evaluated the clinical and immunologic responses of 23 HIV-positive Ugandan volunteers following initiation of antiretroviral therapy (ART). All volunteers achieved and maintained complete viral suppression within the first 3 months of therapy (p > 0.05). CD4 + and CD8 + T cell activation also decreased significantly, although it never reached the level of HIV negative Ugandan volunteers. Viral suppression and CD4 cell recovery were also associated with an improved profile in CD8 + T cell functional markers, but had no effect on HIV-specific proliferation. We conclude that ART in a cohort of therapy-naive Ugandans with AIDS partially restores but does not fully reverse the immune dysfunction observed in chronic HIV infection.

AB - HIV infection is characterized by a decrease in total CD4 cell count, rising viral load, as well as an increase in immune activation levels. Increased activation can lead to an increase in apoptosis and contribute to CD4 depletion. We evaluated the clinical and immunologic responses of 23 HIV-positive Ugandan volunteers following initiation of antiretroviral therapy (ART). All volunteers achieved and maintained complete viral suppression within the first 3 months of therapy (p > 0.05). CD4 + and CD8 + T cell activation also decreased significantly, although it never reached the level of HIV negative Ugandan volunteers. Viral suppression and CD4 cell recovery were also associated with an improved profile in CD8 + T cell functional markers, but had no effect on HIV-specific proliferation. We conclude that ART in a cohort of therapy-naive Ugandans with AIDS partially restores but does not fully reverse the immune dysfunction observed in chronic HIV infection.

UR - http://www.scopus.com/inward/record.url?scp=34547962119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34547962119&partnerID=8YFLogxK

U2 - 10.1089/aid.2006.0309

DO - 10.1089/aid.2006.0309

M3 - Article

VL - 23

SP - 900

EP - 905

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 7

ER -