We report a single pass gas phase route to [11C]CHI based on production of I· from I2 at elevated temperature. I· abstracts H from CH4 to yield ·CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessive amounts of condensed I2 began to trap the 11C. The yield of [11C]CH3I was >50% from [11C]CH4; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after 11CH4 production and can be repeated without system cleanup.
- fiber optic spectrometer
- methyl iodide
- specific activity measurement for C
ASJC Scopus subject areas
- Molecular Medicine
- Radiology Nuclear Medicine and imaging
- Cancer Research