Production of [11C]CH3I by single pass reaction of [11C]CH4 with I2

Jeanne M. Link; Kenneth A. Krohn; John C. Clark

doi:10.1016/S0969-8051(96)00181-3

Production of [¹¹C]CH₃I by single pass reaction of [¹¹C]CH₄ with I₂

Jeanne M. Link, Kenneth A. Krohn, John C. Clark

Research output: Contribution to journal › Article › peer-review

88 Scopus citations

Abstract

We report a single pass gas phase route to [¹¹C]CHI based on production of I· from I₂ at elevated temperature. I· abstracts H from CH₄ to yield ·CH₃, which reacts with I₂ to form CH₃I. A fiber optic spectrometer was used to measure the I₂ vapor concentration. [¹¹C]CH₃I yield increased with I₂ concentration until excessive amounts of condensed I₂ began to trap the ¹¹C. The yield of [¹¹C]CH₃I was >50% from [¹¹C]CH₄; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after ¹¹CH₄ production and can be repeated without system cleanup.

Original language	English (US)
Pages (from-to)	93-97
Number of pages	5
Journal	Nuclear Medicine and Biology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/S0969-8051(96)00181-3
State	Published - Jan 1997
Externally published	Yes

Keywords

fiber optic spectrometer
meta-hydroxyephedrine
methyl iodide
specific activity measurement for C

ASJC Scopus subject areas

Molecular Medicine
Radiology Nuclear Medicine and imaging
Cancer Research

Access to Document

10.1016/S0969-8051(96)00181-3

Cite this

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title = "Production of [11C]CH3I by single pass reaction of [11C]CH4 with I2",

abstract = "We report a single pass gas phase route to [11C]CHI based on production of I· from I2 at elevated temperature. I· abstracts H from CH4 to yield ·CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessive amounts of condensed I2 began to trap the 11C. The yield of [11C]CH3I was >50% from [11C]CH4; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after 11CH4 production and can be repeated without system cleanup.",

keywords = "fiber optic spectrometer, meta-hydroxyephedrine, methyl iodide, specific activity measurement for C",

author = "Link, {Jeanne M.} and Krohn, {Kenneth A.} and Clark, {John C.}",

note = "Funding Information: The authors acknowledge helpful discwsions with Peter Larsen and Martin Orbe and are grateful to Bryan Pruzen for his help with analysis of the spectroscopic data. This research was supported by the National Institutes",

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AU - Link, Jeanne M.

AU - Krohn, Kenneth A.

AU - Clark, John C.

N1 - Funding Information: The authors acknowledge helpful discwsions with Peter Larsen and Martin Orbe and are grateful to Bryan Pruzen for his help with analysis of the spectroscopic data. This research was supported by the National Institutes

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N2 - We report a single pass gas phase route to [11C]CHI based on production of I· from I2 at elevated temperature. I· abstracts H from CH4 to yield ·CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessive amounts of condensed I2 began to trap the 11C. The yield of [11C]CH3I was >50% from [11C]CH4; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after 11CH4 production and can be repeated without system cleanup.

AB - We report a single pass gas phase route to [11C]CHI based on production of I· from I2 at elevated temperature. I· abstracts H from CH4 to yield ·CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessive amounts of condensed I2 began to trap the 11C. The yield of [11C]CH3I was >50% from [11C]CH4; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after 11CH4 production and can be repeated without system cleanup.

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KW - meta-hydroxyephedrine

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KW - specific activity measurement for C

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