Production of [11C]CH3I by single pass reaction of [11C]CH4 with I2

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

We report a single pass gas phase route to [11C]CHI based on production of I· from I2 at elevated temperature. I· abstracts H from CH4 to yield ·CH3, which reacts with I2 to form CH3I. A fiber optic spectrometer was used to measure the I2 vapor concentration. [11C]CH3I yield increased with I2 concentration until excessive amounts of condensed I2 began to trap the 11C. The yield of [11C]CH3I was >50% from [11C]CH4; its specific activity was 12,000 Ci/mmole. The synthesis takes only 4 min after 11CH4 production and can be repeated without system cleanup.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalNuclear Medicine and Biology
Volume24
Issue number1
DOIs
StatePublished - Jan 1 1997

Keywords

  • fiber optic spectrometer
  • meta-hydroxyephedrine
  • methyl iodide
  • specific activity measurement for C

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'Production of [<sup>11</sup>C]CH<sub>3</sub>I by single pass reaction of [<sup>11</sup>C]CH<sub>4</sub> with I<sub>2</sub>'. Together they form a unique fingerprint.

  • Cite this