Production and Purification of Metal Radionuclides for PET Imaging of Disease

Dexing Zeng, Carolyn J. Anderson

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The applications of radiopharmaceuticals labeled with positron-emitting metal radionuclides for positron emission tomography (PET) imaging have been increasing steadily over the past 20 years. The methods used for production and purification of the radionuclides are important for producing high specific activity agents, as this is critical for imaging low capacity receptors that are upregulated in diseased tissues. In this review we outline state-of-the-art methodologies for producing four widely used metal radionuclides (Cu-64, Ga-68, Y-86, and Zr-89) and the various purification schemes that are involved in preparing these radionuclides for their use in PET radiopharmaceuticals.

Original languageEnglish (US)
Pages (from-to)337-344
Number of pages8
JournalSolvent Extraction and Ion Exchange
Volume31
Issue number4
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

Fingerprint

Positron emission tomography
Radioisotopes
Purification
Metals
Imaging techniques
Radiopharmaceuticals
Positrons
Tissue

Keywords

  • molecular imaging
  • PET
  • production
  • radiometals
  • radionuclides

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Production and Purification of Metal Radionuclides for PET Imaging of Disease. / Zeng, Dexing; Anderson, Carolyn J.

In: Solvent Extraction and Ion Exchange, Vol. 31, No. 4, 01.07.2013, p. 337-344.

Research output: Contribution to journalReview article

@article{d55846b0a7aa479a8fac09d65ef13dba,
title = "Production and Purification of Metal Radionuclides for PET Imaging of Disease",
abstract = "The applications of radiopharmaceuticals labeled with positron-emitting metal radionuclides for positron emission tomography (PET) imaging have been increasing steadily over the past 20 years. The methods used for production and purification of the radionuclides are important for producing high specific activity agents, as this is critical for imaging low capacity receptors that are upregulated in diseased tissues. In this review we outline state-of-the-art methodologies for producing four widely used metal radionuclides (Cu-64, Ga-68, Y-86, and Zr-89) and the various purification schemes that are involved in preparing these radionuclides for their use in PET radiopharmaceuticals.",
keywords = "molecular imaging, PET, production, radiometals, radionuclides",
author = "Dexing Zeng and Anderson, {Carolyn J.}",
year = "2013",
month = "7",
day = "1",
doi = "10.1080/07366299.2013.800402",
language = "English (US)",
volume = "31",
pages = "337--344",
journal = "Solvent Extraction and Ion Exchange",
issn = "0736-6299",
publisher = "Taylor and Francis Ltd.",
number = "4",

}

TY - JOUR

T1 - Production and Purification of Metal Radionuclides for PET Imaging of Disease

AU - Zeng, Dexing

AU - Anderson, Carolyn J.

PY - 2013/7/1

Y1 - 2013/7/1

N2 - The applications of radiopharmaceuticals labeled with positron-emitting metal radionuclides for positron emission tomography (PET) imaging have been increasing steadily over the past 20 years. The methods used for production and purification of the radionuclides are important for producing high specific activity agents, as this is critical for imaging low capacity receptors that are upregulated in diseased tissues. In this review we outline state-of-the-art methodologies for producing four widely used metal radionuclides (Cu-64, Ga-68, Y-86, and Zr-89) and the various purification schemes that are involved in preparing these radionuclides for their use in PET radiopharmaceuticals.

AB - The applications of radiopharmaceuticals labeled with positron-emitting metal radionuclides for positron emission tomography (PET) imaging have been increasing steadily over the past 20 years. The methods used for production and purification of the radionuclides are important for producing high specific activity agents, as this is critical for imaging low capacity receptors that are upregulated in diseased tissues. In this review we outline state-of-the-art methodologies for producing four widely used metal radionuclides (Cu-64, Ga-68, Y-86, and Zr-89) and the various purification schemes that are involved in preparing these radionuclides for their use in PET radiopharmaceuticals.

KW - molecular imaging

KW - PET

KW - production

KW - radiometals

KW - radionuclides

UR - http://www.scopus.com/inward/record.url?scp=84880944085&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880944085&partnerID=8YFLogxK

U2 - 10.1080/07366299.2013.800402

DO - 10.1080/07366299.2013.800402

M3 - Review article

AN - SCOPUS:84880944085

VL - 31

SP - 337

EP - 344

JO - Solvent Extraction and Ion Exchange

JF - Solvent Extraction and Ion Exchange

SN - 0736-6299

IS - 4

ER -