Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut

Ajay Kumar Jain, Carel W. le Roux, Puneet Puri, Ali Tavakkoli, Nana Gletsu-Miller, Blandine Laferrère, Richard Kellermayer, John K. DiBaise, Robert G. Martindale, Bruce M. Wolfe

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The goal of the National Institutes of Health–funded American Society for Parenteral and Enteral Nutrition 2017 research workshop (RW) “Gastric Bypass: Role of the Gut” was to focus on the exciting research evaluating gut-derived signals in modulating outcomes after bariatric surgery. Although gastric bypass surgery has undoubted positive effects, the mechanistic basis of improved outcomes cannot be solely explained by caloric restriction. Emerging data suggest that bile acid metabolic pathways, luminal contents, energy balance, gut mucosal integrity, as well as the gut microbiota are significantly modulated after bariatric surgery and may be responsible for the variable outcomes, each of which was rigorously evaluated. The RW served as a timely and novel academic meeting that brought together clinicians and researchers across the scientific spectrum, fostering a unique venue for interdisciplinary collaboration among investigators. It promoted engaging discussion and evolution of new research hypotheses and ideas, driving the development of novel ameliorative, therapeutic, and nonsurgical interventions targeting obesity and its comorbidities. Importantly, a critical evaluation of the current knowledge regarding gut-modulated signaling after bariatric surgery, potential pitfalls, and lacunae were thoroughly addressed.

Original languageEnglish (US)
Pages (from-to)279-295
Number of pages17
JournalJournal of Parenteral and Enteral Nutrition
Volume42
Issue number2
DOIs
StatePublished - Feb 1 2018

Keywords

  • bariatric surgery
  • diabetes
  • endocrinology
  • liver disease
  • metabolic syndrome
  • microbiome
  • obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Jain, A. K., le Roux, C. W., Puri, P., Tavakkoli, A., Gletsu-Miller, N., Laferrère, B., Kellermayer, R., DiBaise, J. K., Martindale, R. G., & Wolfe, B. M. (2018). Proceedings of the 2017 ASPEN Research Workshop—Gastric Bypass: Role of the Gut. Journal of Parenteral and Enteral Nutrition, 42(2), 279-295. https://doi.org/10.1002/jpen.1121