Probing nanoscale tissue structure using light scattering

Steven L. Jacques

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Light scattering by a tissue encodes the size distribution and granularity of the scattering structures in the tissue. (1) Goniometry shows how the angle of photon deflection depends on the structure size. (2) Diffuse light measurements shows that the wavelength dependence of the reduced scattering coefficient governing diffuse light propagation is dependent on the size distribution of scatterers in a tissue. (3) Confocal reflectance is sensitive to the anisotropy of light scattering, which depends on the size distribution of scatterers. (4) Narrowangle planar backscatter of collimated incident white light from a tissue yields a spectrum that encodes the spatial frequency of refractive index fluctuations in the tissue, i.e., the granularity of the tissue. Light scattering is a useful tool for characterizing the nanoscale structure of tissues.

Original languageEnglish (US)
Title of host publicationNovel Techniques in Microscopy, NTM 2015
PublisherOSA - The Optical Society
ISBN (Electronic)9781557529541
DOIs
StatePublished - Apr 6 2015
EventNovel Techniques in Microscopy, NTM 2015 - Vancouver, Canada
Duration: Apr 12 2015Apr 15 2015

Publication series

NameNovel Techniques in Microscopy, NTM 2015

Other

OtherNovel Techniques in Microscopy, NTM 2015
CountryCanada
CityVancouver
Period4/12/154/15/15

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Atomic and Molecular Physics, and Optics

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  • Cite this

    Jacques, S. L. (2015). Probing nanoscale tissue structure using light scattering. In Novel Techniques in Microscopy, NTM 2015 (Novel Techniques in Microscopy, NTM 2015). OSA - The Optical Society. https://doi.org/10.1364/ntm.2015.nw3c.2