Principles of selective ion transport in channels and pumps

Eric Gouaux, Roderick MacKinnon

Research output: Contribution to journalArticle

483 Citations (Scopus)

Abstract

The transport of ions across the membranes of cells and organelles is a prerequisite for many of life's processes. Transport often involves very precise selectivity for specific ions. Recently, atomic-resolution structures have been determined for channels or pumps that are selective for sodium, potassium, calcium, and chloride: four of the most abundant ions in biology. From these structures we can begin to understand the principles of selective ion transport in terms of the architecture and detailed chemistry of the ion conduction pathways.

Original languageEnglish (US)
Pages (from-to)1461-1465
Number of pages5
JournalScience
Volume310
Issue number5753
DOIs
StatePublished - Dec 2 2005

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Ion Transport
Ions
Sodium-Potassium-Exchanging ATPase
Calcium Chloride
Potassium Chloride
Organelles
Cell Membrane

ASJC Scopus subject areas

  • General

Cite this

Principles of selective ion transport in channels and pumps. / Gouaux, Eric; MacKinnon, Roderick.

In: Science, Vol. 310, No. 5753, 02.12.2005, p. 1461-1465.

Research output: Contribution to journalArticle

Gouaux, Eric ; MacKinnon, Roderick. / Principles of selective ion transport in channels and pumps. In: Science. 2005 ; Vol. 310, No. 5753. pp. 1461-1465.
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