Primitive pelvic sarcoma resembling clear cell sarcoma of kidney

Douglas Weeks, Richelle Malott, C. Zuppan, G. W. Mierau, J. B. Beckwith

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Clear cell sarcoma of kidney (CCSK) is an aggressive childhood renal tumor of unknown histogenesis that has not been reported to occur outside the kidney. The article describes an extrarenal neoplasm arising in the pelvic soft tissues of a 13-year-old boy that was composed predominantly of uniform mesenchymal cells with optically clear cytoplasm supported by an arborizing network of small blood vessels, which was indistinguishable in appearance from CCSK. The electron microscopic findings, although nonspecific, were essentially identical to those of CCSK, with tumor cells displaying fine chromatin, electron-lucent cytoplasm, and intercellular collagen but no evidence of tissue-specific differentiation. Immunocytochemical studies showed positivity for vimentin but negative results for desmin, myoglobin, cytokeratin, epithelial membrane antigen, S-100 protein, neuron-specific enolase and factor VIII-related antigen. Tumor cells were also nonreactive with Ulex lectin. This unusual pelvic tumor and CCSK may both derive from primitive mesenchymal cells and may represent phenotypic but not necessarily histogenetic analogs.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalUltrastructural Pathology
Volume15
Issue number4-5
StatePublished - 1991
Externally publishedYes

Fingerprint

Clear Cell Sarcoma
kidneys
Sarcoma
Tumors
cancer
Kidney
tumors
Antigens
cells
S100 Proteins
cytoplasm
Cells
antigens
Neoplasms
Tissue
Electrons
Blood vessels
Cytoplasm
Collagen
Neurons

Keywords

  • Childhood sarcoma
  • Clear cell sarcoma of kidney
  • Electron microscopy
  • Immunocytochemistry
  • Primitive sarcoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Instrumentation
  • Structural Biology

Cite this

Weeks, D., Malott, R., Zuppan, C., Mierau, G. W., & Beckwith, J. B. (1991). Primitive pelvic sarcoma resembling clear cell sarcoma of kidney. Ultrastructural Pathology, 15(4-5), 403-408.

Primitive pelvic sarcoma resembling clear cell sarcoma of kidney. / Weeks, Douglas; Malott, Richelle; Zuppan, C.; Mierau, G. W.; Beckwith, J. B.

In: Ultrastructural Pathology, Vol. 15, No. 4-5, 1991, p. 403-408.

Research output: Contribution to journalArticle

Weeks, D, Malott, R, Zuppan, C, Mierau, GW & Beckwith, JB 1991, 'Primitive pelvic sarcoma resembling clear cell sarcoma of kidney', Ultrastructural Pathology, vol. 15, no. 4-5, pp. 403-408.
Weeks D, Malott R, Zuppan C, Mierau GW, Beckwith JB. Primitive pelvic sarcoma resembling clear cell sarcoma of kidney. Ultrastructural Pathology. 1991;15(4-5):403-408.
Weeks, Douglas ; Malott, Richelle ; Zuppan, C. ; Mierau, G. W. ; Beckwith, J. B. / Primitive pelvic sarcoma resembling clear cell sarcoma of kidney. In: Ultrastructural Pathology. 1991 ; Vol. 15, No. 4-5. pp. 403-408.
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