Primate models for the assisted reproductive technologies and embryonic stem cell biology

Don P. Wolf; Shoukhrat Mitalipov; James A. Byrne

doi:10.1007/978-1-59745-285-4_42

Primate models for the assisted reproductive technologies and embryonic stem cell biology

Don P. Wolf, Shoukhrat Mitalipov, James A. Byrne

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Nonhuman primates (NHPs) represent clinically relevant animal models used in studies on the etiology and treatment of human diseases. In the context of reproduction, NHP models are relevant to research interests as diverse as the etiology and treatment of infertility and contraceptive development to an evaluation of cell or tissue-based therapies of disease employing embryonic stem cell-derived phenotypes. The assisted reproductive technologies (ARTs) are used in the production of animals carrying desired MHC alleles for HIV vaccine development and could be used in the production of genetically identical animals by somatic cell nuclear transfer (SCNT). SCNT in turn is relevant to rescuing the unique genetics of aging or even deceased animals, to testing the efficacy of therapeutic cloning, and in combination with gene targeting, to creating monkey models of genetically based, neurodegenerative diseases. Since most NHP experience in applying the ARTs and in deriving embryonic stem cells (ESCs) involves Old World monkeys, principally rhesus and cynomolgus macaques and baboons, studies with these species will be featured in this chapter.

Original language	English (US)
Title of host publication	Source Book of Models for Biomedical Research
Publisher	Humana Press
Pages	397-404
Number of pages	8
ISBN (Print)	9781588299338
DOIs	https://doi.org/10.1007/978-1-59745-285-4_42
State	Published - Dec 1 2008

Keywords

Assisted reproductive technology
Cloning
Embryonic stem cells
Nonhuman primates

ASJC Scopus subject areas

Medicine(all)

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AU - Byrne, James A.

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N2 - Nonhuman primates (NHPs) represent clinically relevant animal models used in studies on the etiology and treatment of human diseases. In the context of reproduction, NHP models are relevant to research interests as diverse as the etiology and treatment of infertility and contraceptive development to an evaluation of cell or tissue-based therapies of disease employing embryonic stem cell-derived phenotypes. The assisted reproductive technologies (ARTs) are used in the production of animals carrying desired MHC alleles for HIV vaccine development and could be used in the production of genetically identical animals by somatic cell nuclear transfer (SCNT). SCNT in turn is relevant to rescuing the unique genetics of aging or even deceased animals, to testing the efficacy of therapeutic cloning, and in combination with gene targeting, to creating monkey models of genetically based, neurodegenerative diseases. Since most NHP experience in applying the ARTs and in deriving embryonic stem cells (ESCs) involves Old World monkeys, principally rhesus and cynomolgus macaques and baboons, studies with these species will be featured in this chapter.

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Primate models for the assisted reproductive technologies and embryonic stem cell biology

Abstract

Keywords

ASJC Scopus subject areas

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