Primate models for the assisted reproductive technologies and embryonic stem cell biology

Don P. Wolf, Shoukhrat Mitalipov, James A. Byrne

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Nonhuman primates (NHPs) represent clinically relevant animal models used in studies on the etiology and treatment of human diseases. In the context of reproduction, NHP models are relevant to research interests as diverse as the etiology and treatment of infertility and contraceptive development to an evaluation of cell or tissue-based therapies of disease employing embryonic stem cell-derived phenotypes. The assisted reproductive technologies (ARTs) are used in the production of animals carrying desired MHC alleles for HIV vaccine development and could be used in the production of genetically identical animals by somatic cell nuclear transfer (SCNT). SCNT in turn is relevant to rescuing the unique genetics of aging or even deceased animals, to testing the efficacy of therapeutic cloning, and in combination with gene targeting, to creating monkey models of genetically based, neurodegenerative diseases. Since most NHP experience in applying the ARTs and in deriving embryonic stem cells (ESCs) involves Old World monkeys, principally rhesus and cynomolgus macaques and baboons, studies with these species will be featured in this chapter.

    Original languageEnglish (US)
    Title of host publicationSource Book of Models for Biomedical Research
    PublisherHumana Press
    Pages397-404
    Number of pages8
    ISBN (Print)9781588299338
    DOIs
    StatePublished - 2008

    Fingerprint

    Assisted Reproductive Techniques
    Embryonic Stem Cells
    Primates
    Cell Biology
    Cercopithecidae
    AIDS Vaccines
    Gene Targeting
    Papio
    Cell- and Tissue-Based Therapy
    Contraceptive Agents
    Macaca mulatta
    Neurodegenerative Diseases
    Infertility
    Haplorhini
    Reproduction
    Organism Cloning
    Therapeutics
    Animal Models
    Alleles
    Phenotype

    Keywords

    • Assisted reproductive technology
    • Cloning
    • Embryonic stem cells
    • Nonhuman primates

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Wolf, D. P., Mitalipov, S., & Byrne, J. A. (2008). Primate models for the assisted reproductive technologies and embryonic stem cell biology. In Source Book of Models for Biomedical Research (pp. 397-404). Humana Press. https://doi.org/10.1007/978-1-59745-285-4_42

    Primate models for the assisted reproductive technologies and embryonic stem cell biology. / Wolf, Don P.; Mitalipov, Shoukhrat; Byrne, James A.

    Source Book of Models for Biomedical Research. Humana Press, 2008. p. 397-404.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Wolf, DP, Mitalipov, S & Byrne, JA 2008, Primate models for the assisted reproductive technologies and embryonic stem cell biology. in Source Book of Models for Biomedical Research. Humana Press, pp. 397-404. https://doi.org/10.1007/978-1-59745-285-4_42
    Wolf DP, Mitalipov S, Byrne JA. Primate models for the assisted reproductive technologies and embryonic stem cell biology. In Source Book of Models for Biomedical Research. Humana Press. 2008. p. 397-404 https://doi.org/10.1007/978-1-59745-285-4_42
    Wolf, Don P. ; Mitalipov, Shoukhrat ; Byrne, James A. / Primate models for the assisted reproductive technologies and embryonic stem cell biology. Source Book of Models for Biomedical Research. Humana Press, 2008. pp. 397-404
    @inbook{9bbe1f7f176e486ba8164c5b457edcbd,
    title = "Primate models for the assisted reproductive technologies and embryonic stem cell biology",
    abstract = "Nonhuman primates (NHPs) represent clinically relevant animal models used in studies on the etiology and treatment of human diseases. In the context of reproduction, NHP models are relevant to research interests as diverse as the etiology and treatment of infertility and contraceptive development to an evaluation of cell or tissue-based therapies of disease employing embryonic stem cell-derived phenotypes. The assisted reproductive technologies (ARTs) are used in the production of animals carrying desired MHC alleles for HIV vaccine development and could be used in the production of genetically identical animals by somatic cell nuclear transfer (SCNT). SCNT in turn is relevant to rescuing the unique genetics of aging or even deceased animals, to testing the efficacy of therapeutic cloning, and in combination with gene targeting, to creating monkey models of genetically based, neurodegenerative diseases. Since most NHP experience in applying the ARTs and in deriving embryonic stem cells (ESCs) involves Old World monkeys, principally rhesus and cynomolgus macaques and baboons, studies with these species will be featured in this chapter.",
    keywords = "Assisted reproductive technology, Cloning, Embryonic stem cells, Nonhuman primates",
    author = "Wolf, {Don P.} and Shoukhrat Mitalipov and Byrne, {James A.}",
    year = "2008",
    doi = "10.1007/978-1-59745-285-4_42",
    language = "English (US)",
    isbn = "9781588299338",
    pages = "397--404",
    booktitle = "Source Book of Models for Biomedical Research",
    publisher = "Humana Press",

    }

    TY - CHAP

    T1 - Primate models for the assisted reproductive technologies and embryonic stem cell biology

    AU - Wolf, Don P.

    AU - Mitalipov, Shoukhrat

    AU - Byrne, James A.

    PY - 2008

    Y1 - 2008

    N2 - Nonhuman primates (NHPs) represent clinically relevant animal models used in studies on the etiology and treatment of human diseases. In the context of reproduction, NHP models are relevant to research interests as diverse as the etiology and treatment of infertility and contraceptive development to an evaluation of cell or tissue-based therapies of disease employing embryonic stem cell-derived phenotypes. The assisted reproductive technologies (ARTs) are used in the production of animals carrying desired MHC alleles for HIV vaccine development and could be used in the production of genetically identical animals by somatic cell nuclear transfer (SCNT). SCNT in turn is relevant to rescuing the unique genetics of aging or even deceased animals, to testing the efficacy of therapeutic cloning, and in combination with gene targeting, to creating monkey models of genetically based, neurodegenerative diseases. Since most NHP experience in applying the ARTs and in deriving embryonic stem cells (ESCs) involves Old World monkeys, principally rhesus and cynomolgus macaques and baboons, studies with these species will be featured in this chapter.

    AB - Nonhuman primates (NHPs) represent clinically relevant animal models used in studies on the etiology and treatment of human diseases. In the context of reproduction, NHP models are relevant to research interests as diverse as the etiology and treatment of infertility and contraceptive development to an evaluation of cell or tissue-based therapies of disease employing embryonic stem cell-derived phenotypes. The assisted reproductive technologies (ARTs) are used in the production of animals carrying desired MHC alleles for HIV vaccine development and could be used in the production of genetically identical animals by somatic cell nuclear transfer (SCNT). SCNT in turn is relevant to rescuing the unique genetics of aging or even deceased animals, to testing the efficacy of therapeutic cloning, and in combination with gene targeting, to creating monkey models of genetically based, neurodegenerative diseases. Since most NHP experience in applying the ARTs and in deriving embryonic stem cells (ESCs) involves Old World monkeys, principally rhesus and cynomolgus macaques and baboons, studies with these species will be featured in this chapter.

    KW - Assisted reproductive technology

    KW - Cloning

    KW - Embryonic stem cells

    KW - Nonhuman primates

    UR - http://www.scopus.com/inward/record.url?scp=84891409286&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84891409286&partnerID=8YFLogxK

    U2 - 10.1007/978-1-59745-285-4_42

    DO - 10.1007/978-1-59745-285-4_42

    M3 - Chapter

    AN - SCOPUS:84891409286

    SN - 9781588299338

    SP - 397

    EP - 404

    BT - Source Book of Models for Biomedical Research

    PB - Humana Press

    ER -