Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia

Lee J. Martin, Ansgar Brambrink, Raymond C. Koehler, Richard J. Traystman

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Cerebral hypoxia-ischemia causes encephalopathy and neurologic disabilities in newborns by unclear mechanisms. We tested the hypothesis that hypoxia-ischemia causes brain damage in newborns that is system-preferential and related to regional oxidative metabolism. One-week-old piglets were subjected to 30 minutes of hypoxia and then seven minutes of airway occlusion, producing asphyxic cardiac arrest, followed by cardiopulmonary resuscitation and four-day recovery. Brain injury in hypoxic-ischemic piglets (n = 6) compared to controls (n = 5) was analyzed by hematoxylin-eosin, Nissl, and silver staining; relationships between regional vulnerability and oxidative metabolism were evaluated by cytochrome oxidase histochemistry. Profile counting-based estimates showed that 13% and 27% of neurons in layers II/III and layers IV/V of somatosensory cortex had ischemic cytopathology, respectively; CA1 neuronal perikarya appeared undamaged, and

Original languageEnglish (US)
Pages (from-to)262-285
Number of pages24
JournalJournal of Comparative Neurology
Volume377
Issue number2
DOIs
StatePublished - Jan 13 1997
Externally publishedYes

Fingerprint

Brain Hypoxia-Ischemia
Prosencephalon
Ischemia
Silver Staining
Somatosensory Cortex
Cardiopulmonary Resuscitation
Brain
Brain Diseases
Electron Transport Complex IV
Hematoxylin
Eosine Yellowish-(YS)
Heart Arrest
Brain Injuries
Nervous System
Neurons
Hypoxia

Keywords

  • basal ganglia
  • cytochrome oxidase
  • neonatal encephalopathy
  • O deprivation
  • somatosensory system

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia. / Martin, Lee J.; Brambrink, Ansgar; Koehler, Raymond C.; Traystman, Richard J.

In: Journal of Comparative Neurology, Vol. 377, No. 2, 13.01.1997, p. 262-285.

Research output: Contribution to journalArticle

Martin, Lee J. ; Brambrink, Ansgar ; Koehler, Raymond C. ; Traystman, Richard J. / Primary sensory and forebrain motor systems in the newborn brain are preferentially damaged by hypoxia-ischemia. In: Journal of Comparative Neurology. 1997 ; Vol. 377, No. 2. pp. 262-285.
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