Primary sclerosing cholangitis-associated inflammatory bowel disease

Blair Fennimore, Emilie H. Regner, Mark E. Gerich

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease (IBD). Although there is a clear genetic association between PSC and IBD, the underlying pathogenesis linking these diseases remains unclear. Many studies describe PSC-associated IBD (PSC-IBD) as a distinct phenotype characterized by extensive colitis with predominantly right colon inflammation and rectal sparing as well as a dramatically increased risk of colorectal cancer (CRC). The prevention and management of unfavorable outcomes related to colonic dysplasia are key aspects to the care of patients with PSC.-IBD. Additional challenges are posed by the management of IBD in the setting of liver transplantation. In summary, PSC-IBD is a common occurrence among PSC patients that presents distinct diagnostic, prognostic, and management issues with additional unique considerations in the posttransplant setting.

Original languageEnglish (US)
Title of host publicationPrimary Sclerosing Cholangitis
Subtitle of host publicationCurrent Understanding, Management, and Future Developments
PublisherSpringer International Publishing
Pages29-40
Number of pages12
ISBN (Electronic)9783319409085
ISBN (Print)9783319409061
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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