Primary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease (IBD). Although there is a clear genetic association between PSC and IBD, the underlying pathogenesis linking these diseases remains unclear. Many studies describe PSC-associated IBD (PSC-IBD) as a distinct phenotype characterized by extensive colitis with predominantly right colon inflammation and rectal sparing as well as a dramatically increased risk of colorectal cancer (CRC). The prevention and management of unfavorable outcomes related to colonic dysplasia are key aspects to the care of patients with PSC.-IBD. Additional challenges are posed by the management of IBD in the setting of liver transplantation. In summary, PSC-IBD is a common occurrence among PSC patients that presents distinct diagnostic, prognostic, and management issues with additional unique considerations in the posttransplant setting.
|Original language||English (US)|
|Title of host publication||Primary Sclerosing Cholangitis|
|Subtitle of host publication||Current Understanding, Management, and Future Developments|
|Publisher||Springer International Publishing|
|Number of pages||12|
|State||Published - Jan 1 2016|
ASJC Scopus subject areas