Primary Sarcomas of the Lung

Regan M. Duffy, Amanda VanSandt, Alan B. Sandler

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Primary pulmonary sarcomas are a rare group of pulmonary malignancies, outnumbered by bronchogenic carcinomas by a factor of 500:1. These tumors are often difficult to differentiate and characterize on the basis of morphology alone, and diagnosis frequently depends upon immunohistochemical and cytogenetic analysis. Primary pulmonary sarcomas are typically very advanced at the time of diagnosis, with symptoms related to tumor invasion or postobstructive pneumonia commonly prompting evaluation. Some patients, however, are asymptomatic at the time of diagnosis, and primary pulmonary sarcoma is an incidental finding on an imaging study. The clinical symptoms and radiographic findings of primary pulmonary sarcoma are myriad and can resemble many other disease entities, so primary pulmonary sarcoma needs to be entertained in the differential diagnosis during evaluation of other diseases. Complete surgical resection remains the only therapeutic approach for cure but due to advanced stage at diagnosis, many patients are not eligible for resection. Chemotherapy and radiation therapy are important for treatment but newer, more efficacious therapeutic agents are needed.

Original languageEnglish (US)
Title of host publicationTextbook of Uncommon Cancer
PublisherJohn Wiley and Sons
Pages303-317
Number of pages15
ISBN (Print)9781118083734
DOIs
StatePublished - Sep 20 2012

Fingerprint

Sarcoma
Lung
Neoplasms
Incidental Findings
Bronchogenic Carcinoma
Cytogenetic Analysis
Pneumonia
Differential Diagnosis
Radiotherapy
Therapeutics
Drug Therapy

Keywords

  • Angiosarcoma
  • Epithelioid hemangioendothelioma
  • Kaposi sarcoma
  • Leiomyosarcoma
  • Pulmonary sarcoma
  • Rhabdomyosarcoma
  • Solitary fibrous tumor/hemangiopericytoma
  • Synovial sarcoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Duffy, R. M., VanSandt, A., & Sandler, A. B. (2012). Primary Sarcomas of the Lung. In Textbook of Uncommon Cancer (pp. 303-317). John Wiley and Sons. https://doi.org/10.1002/9781118464557.ch21

Primary Sarcomas of the Lung. / Duffy, Regan M.; VanSandt, Amanda; Sandler, Alan B.

Textbook of Uncommon Cancer. John Wiley and Sons, 2012. p. 303-317.

Research output: Chapter in Book/Report/Conference proceedingChapter

Duffy, RM, VanSandt, A & Sandler, AB 2012, Primary Sarcomas of the Lung. in Textbook of Uncommon Cancer. John Wiley and Sons, pp. 303-317. https://doi.org/10.1002/9781118464557.ch21
Duffy RM, VanSandt A, Sandler AB. Primary Sarcomas of the Lung. In Textbook of Uncommon Cancer. John Wiley and Sons. 2012. p. 303-317 https://doi.org/10.1002/9781118464557.ch21
Duffy, Regan M. ; VanSandt, Amanda ; Sandler, Alan B. / Primary Sarcomas of the Lung. Textbook of Uncommon Cancer. John Wiley and Sons, 2012. pp. 303-317
@inbook{1189f3d047fc47178dd3dedff2bbec06,
title = "Primary Sarcomas of the Lung",
abstract = "Primary pulmonary sarcomas are a rare group of pulmonary malignancies, outnumbered by bronchogenic carcinomas by a factor of 500:1. These tumors are often difficult to differentiate and characterize on the basis of morphology alone, and diagnosis frequently depends upon immunohistochemical and cytogenetic analysis. Primary pulmonary sarcomas are typically very advanced at the time of diagnosis, with symptoms related to tumor invasion or postobstructive pneumonia commonly prompting evaluation. Some patients, however, are asymptomatic at the time of diagnosis, and primary pulmonary sarcoma is an incidental finding on an imaging study. The clinical symptoms and radiographic findings of primary pulmonary sarcoma are myriad and can resemble many other disease entities, so primary pulmonary sarcoma needs to be entertained in the differential diagnosis during evaluation of other diseases. Complete surgical resection remains the only therapeutic approach for cure but due to advanced stage at diagnosis, many patients are not eligible for resection. Chemotherapy and radiation therapy are important for treatment but newer, more efficacious therapeutic agents are needed.",
keywords = "Angiosarcoma, Epithelioid hemangioendothelioma, Kaposi sarcoma, Leiomyosarcoma, Pulmonary sarcoma, Rhabdomyosarcoma, Solitary fibrous tumor/hemangiopericytoma, Synovial sarcoma",
author = "Duffy, {Regan M.} and Amanda VanSandt and Sandler, {Alan B.}",
year = "2012",
month = "9",
day = "20",
doi = "10.1002/9781118464557.ch21",
language = "English (US)",
isbn = "9781118083734",
pages = "303--317",
booktitle = "Textbook of Uncommon Cancer",
publisher = "John Wiley and Sons",

}

TY - CHAP

T1 - Primary Sarcomas of the Lung

AU - Duffy, Regan M.

AU - VanSandt, Amanda

AU - Sandler, Alan B.

PY - 2012/9/20

Y1 - 2012/9/20

N2 - Primary pulmonary sarcomas are a rare group of pulmonary malignancies, outnumbered by bronchogenic carcinomas by a factor of 500:1. These tumors are often difficult to differentiate and characterize on the basis of morphology alone, and diagnosis frequently depends upon immunohistochemical and cytogenetic analysis. Primary pulmonary sarcomas are typically very advanced at the time of diagnosis, with symptoms related to tumor invasion or postobstructive pneumonia commonly prompting evaluation. Some patients, however, are asymptomatic at the time of diagnosis, and primary pulmonary sarcoma is an incidental finding on an imaging study. The clinical symptoms and radiographic findings of primary pulmonary sarcoma are myriad and can resemble many other disease entities, so primary pulmonary sarcoma needs to be entertained in the differential diagnosis during evaluation of other diseases. Complete surgical resection remains the only therapeutic approach for cure but due to advanced stage at diagnosis, many patients are not eligible for resection. Chemotherapy and radiation therapy are important for treatment but newer, more efficacious therapeutic agents are needed.

AB - Primary pulmonary sarcomas are a rare group of pulmonary malignancies, outnumbered by bronchogenic carcinomas by a factor of 500:1. These tumors are often difficult to differentiate and characterize on the basis of morphology alone, and diagnosis frequently depends upon immunohistochemical and cytogenetic analysis. Primary pulmonary sarcomas are typically very advanced at the time of diagnosis, with symptoms related to tumor invasion or postobstructive pneumonia commonly prompting evaluation. Some patients, however, are asymptomatic at the time of diagnosis, and primary pulmonary sarcoma is an incidental finding on an imaging study. The clinical symptoms and radiographic findings of primary pulmonary sarcoma are myriad and can resemble many other disease entities, so primary pulmonary sarcoma needs to be entertained in the differential diagnosis during evaluation of other diseases. Complete surgical resection remains the only therapeutic approach for cure but due to advanced stage at diagnosis, many patients are not eligible for resection. Chemotherapy and radiation therapy are important for treatment but newer, more efficacious therapeutic agents are needed.

KW - Angiosarcoma

KW - Epithelioid hemangioendothelioma

KW - Kaposi sarcoma

KW - Leiomyosarcoma

KW - Pulmonary sarcoma

KW - Rhabdomyosarcoma

KW - Solitary fibrous tumor/hemangiopericytoma

KW - Synovial sarcoma

UR - http://www.scopus.com/inward/record.url?scp=84886826881&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886826881&partnerID=8YFLogxK

U2 - 10.1002/9781118464557.ch21

DO - 10.1002/9781118464557.ch21

M3 - Chapter

AN - SCOPUS:84886826881

SN - 9781118083734

SP - 303

EP - 317

BT - Textbook of Uncommon Cancer

PB - John Wiley and Sons

ER -