Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (DLBCL) in a patient taking fingolimod

Abby Wills, Guang Fan, Edward Kim, Craig Y. Okada, Kevin P. White, R. Samuel Hopkins

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A 55-year-old man with relapsing-remitting multiple sclerosis on fingolimod presented to the dermatology clinic with skin lesions on the left temple and cheek. Histopathology showed a diffuse infiltrate of enlarged, atypical lymphocytes throughout the dermis with an overlying grenz zone and a subpopulation of scattered smaller lymphocytes and plasma cells. Epstein-Barr virus-encoded RNA in situ hybridization stain was positive. Based on the morphologic and immunophenotypic findings, a diagnosis of EBV-positive diffuse large B-cell lymphoma was made. This case aims to raise awareness for the dermatologist that patients on fingolimod may be at increased risk of lymphoproliferative disorders.

Original languageEnglish (US)
JournalDermatology Online Journal
Volume25
Issue number9
StatePublished - Sep 15 2019

ASJC Scopus subject areas

  • Dermatology

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