Abstract
A 55-year-old man with relapsing-remitting multiple sclerosis on fingolimod presented to the dermatology clinic with skin lesions on the left temple and cheek. Histopathology showed a diffuse infiltrate of enlarged, atypical lymphocytes throughout the dermis with an overlying grenz zone and a subpopulation of scattered smaller lymphocytes and plasma cells. Epstein-Barr virusencoded RNA in situ hybridization stain was positive. Based on the morphologic and immunophenotypic findings, a diagnosis of EBV-positive diffuse large Bcell lymphoma was made. This case aims to raise awareness for the dermatologist that patients on fingolimod may be at increased risk of lymphoproliferative disorders.
Original language | English (US) |
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Article number | A364 |
Journal | Dermatology Online Journal |
Volume | 25 |
Issue number | 9 |
DOIs | |
State | Published - 2019 |
Keywords
- DLBCL
- Diffuse large Bcell lymphoma
- EBV-positive DLBCL
- Fingolimod
- Multiple sclerosis
- Primary cutaneous B-cell lymphoma
- Primary cutaneous Epstein-Barr virus-positive lymphoma
- Primary cutaneous diffuse large B-cell lymphoma
- Primary cutaneous lymphoma
ASJC Scopus subject areas
- Dermatology