Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report

S. A. Grimm; C. A. McCannel; A. M.P. Omuro; A. J.M. Ferreri; J. Y. Blay; E. A. Neuwelt; T. Siegal; T. Batchelor; K. Jahnke; T. N. Shenkier; A. J. Hall; F. Graus; U. Herrlinger; D. Schiff; J. Raizer; J. Rubenstein; N. Laperriere; E. Thiel; N. Doolittle; F. M. Iwamoto; L. E. Abrey

doi:10.1212/01.wnl.0000327672.04729.8c

Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report

S. A. Grimm, C. A. McCannel, A. M.P. Omuro, A. J.M. Ferreri, J. Y. Blay, E. A. Neuwelt, T. Siegal, T. Batchelor, K. Jahnke, T. N. Shenkier, A. J. Hall, F. Graus, U. Herrlinger, D. Schiff, J. Raizer, J. Rubenstein, N. Laperriere, E. Thiel, N. Doolittle, F. M. IwamotoL. E. Abrey

Neurology

Research output: Contribution to journal › Article › peer-review

175 Scopus citations

Abstract

Objective: To describe the demographics, diagnostic details, therapeutic management, and outcome in patients with primary CNS lymphoma (PCNSL) with ocular involvement. Methods: A retrospective study of 221 patients was assembled from 16 centers in seven countries. Only HIV-negative, immunocompetent patients with brain and ocular lymphoma were included; none had systemic lymphoma. Results: Median age at diagnosis was 60. Fifty-seven percent were women. Median Eastern Cooperative Oncology Group performance status was 2. Ocular disturbance and behavioral/cognitive changes were the most common presenting symptoms. Diagnosis of lymphoma was made by brain biopsy (147), vitrectomy (65), or CSF cytology (11). Diagnosis of intraocular lymphoma was made by vitrectomy/choroidal/retinal biopsy (90) or clinical ophthalmic examination (141). CSF cytology was positive in 23%. Treatment information was available for 176 patients. A total of 102 received dedicated ocular therapy (ocular radiotherapy 79, intravitreal methotrexate 22, and both 1) in addition to treatment for their brain lymphoma. Sixty-nine percent progressed at a median of 13 months; sites of progression included brain 52%, eyes 19%, brain and eyes 12%, and systemic 2%. Patients treated with local ocular therapy did not have a statistically significant decreased risk of failing in the eyes (p ≤ 0.7). Median progression free survival and overall survival for the entire cohort were 18 and 31 months. Conclusion: This is the largest reported series of primary CNS lymphoma (PCNSL) with intraocular involvement. Progression free and overall survival was similar to that reported with PCNSL. Dedicated ocular therapy improved disease control but did not affect overall survival.

Original language	English (US)
Pages (from-to)	1355-1360
Number of pages	6
Journal	Neurology
Volume	71
Issue number	17
DOIs	https://doi.org/10.1212/01.wnl.0000327672.04729.8c
State	Published - Oct 21 2008

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/01.wnl.0000327672.04729.8c

Cite this

Grimm, S. A., McCannel, C. A., Omuro, A. M. P., Ferreri, A. J. M., Blay, J. Y., Neuwelt, E. A., Siegal, T., Batchelor, T., Jahnke, K., Shenkier, T. N., Hall, A. J., Graus, F., Herrlinger, U., Schiff, D., Raizer, J., Rubenstein, J., Laperriere, N., Thiel, E., Doolittle, N., ... Abrey, L. E. (2008). Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report. Neurology, 71(17), 1355-1360. https://doi.org/10.1212/01.wnl.0000327672.04729.8c

Grimm, SA, McCannel, CA, Omuro, AMP, Ferreri, AJM, Blay, JY, Neuwelt, EA, Siegal, T, Batchelor, T, Jahnke, K, Shenkier, TN, Hall, AJ, Graus, F, Herrlinger, U, Schiff, D, Raizer, J, Rubenstein, J, Laperriere, N, Thiel, E, Doolittle, N, Iwamoto, FM & Abrey, LE 2008, 'Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report', Neurology, vol. 71, no. 17, pp. 1355-1360. https://doi.org/10.1212/01.wnl.0000327672.04729.8c

@article{8d18fbfee9774463876a489767971f17,

title = "Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report",

abstract = "Objective: To describe the demographics, diagnostic details, therapeutic management, and outcome in patients with primary CNS lymphoma (PCNSL) with ocular involvement. Methods: A retrospective study of 221 patients was assembled from 16 centers in seven countries. Only HIV-negative, immunocompetent patients with brain and ocular lymphoma were included; none had systemic lymphoma. Results: Median age at diagnosis was 60. Fifty-seven percent were women. Median Eastern Cooperative Oncology Group performance status was 2. Ocular disturbance and behavioral/cognitive changes were the most common presenting symptoms. Diagnosis of lymphoma was made by brain biopsy (147), vitrectomy (65), or CSF cytology (11). Diagnosis of intraocular lymphoma was made by vitrectomy/choroidal/retinal biopsy (90) or clinical ophthalmic examination (141). CSF cytology was positive in 23%. Treatment information was available for 176 patients. A total of 102 received dedicated ocular therapy (ocular radiotherapy 79, intravitreal methotrexate 22, and both 1) in addition to treatment for their brain lymphoma. Sixty-nine percent progressed at a median of 13 months; sites of progression included brain 52%, eyes 19%, brain and eyes 12%, and systemic 2%. Patients treated with local ocular therapy did not have a statistically significant decreased risk of failing in the eyes (p ≤ 0.7). Median progression free survival and overall survival for the entire cohort were 18 and 31 months. Conclusion: This is the largest reported series of primary CNS lymphoma (PCNSL) with intraocular involvement. Progression free and overall survival was similar to that reported with PCNSL. Dedicated ocular therapy improved disease control but did not affect overall survival.",

author = "Grimm, {S. A.} and McCannel, {C. A.} and Omuro, {A. M.P.} and Ferreri, {A. J.M.} and Blay, {J. Y.} and Neuwelt, {E. A.} and T. Siegal and T. Batchelor and K. Jahnke and Shenkier, {T. N.} and Hall, {A. J.} and F. Graus and U. Herrlinger and D. Schiff and J. Raizer and J. Rubenstein and N. Laperriere and E. Thiel and N. Doolittle and Iwamoto, {F. M.} and Abrey, {L. E.}",

year = "2008",

month = oct,

day = "21",

doi = "10.1212/01.wnl.0000327672.04729.8c",

language = "English (US)",

volume = "71",

pages = "1355--1360",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "17",

}

TY - JOUR

T1 - Primary CNS lymphoma with intraocular involvement

T2 - International PCNSL Collaborative Group Report

AU - Grimm, S. A.

AU - McCannel, C. A.

AU - Omuro, A. M.P.

AU - Ferreri, A. J.M.

AU - Blay, J. Y.

AU - Neuwelt, E. A.

AU - Siegal, T.

AU - Batchelor, T.

AU - Jahnke, K.

AU - Shenkier, T. N.

AU - Hall, A. J.

AU - Graus, F.

AU - Herrlinger, U.

AU - Schiff, D.

AU - Raizer, J.

AU - Rubenstein, J.

AU - Laperriere, N.

AU - Thiel, E.

AU - Doolittle, N.

AU - Iwamoto, F. M.

AU - Abrey, L. E.

PY - 2008/10/21

Y1 - 2008/10/21

N2 - Objective: To describe the demographics, diagnostic details, therapeutic management, and outcome in patients with primary CNS lymphoma (PCNSL) with ocular involvement. Methods: A retrospective study of 221 patients was assembled from 16 centers in seven countries. Only HIV-negative, immunocompetent patients with brain and ocular lymphoma were included; none had systemic lymphoma. Results: Median age at diagnosis was 60. Fifty-seven percent were women. Median Eastern Cooperative Oncology Group performance status was 2. Ocular disturbance and behavioral/cognitive changes were the most common presenting symptoms. Diagnosis of lymphoma was made by brain biopsy (147), vitrectomy (65), or CSF cytology (11). Diagnosis of intraocular lymphoma was made by vitrectomy/choroidal/retinal biopsy (90) or clinical ophthalmic examination (141). CSF cytology was positive in 23%. Treatment information was available for 176 patients. A total of 102 received dedicated ocular therapy (ocular radiotherapy 79, intravitreal methotrexate 22, and both 1) in addition to treatment for their brain lymphoma. Sixty-nine percent progressed at a median of 13 months; sites of progression included brain 52%, eyes 19%, brain and eyes 12%, and systemic 2%. Patients treated with local ocular therapy did not have a statistically significant decreased risk of failing in the eyes (p ≤ 0.7). Median progression free survival and overall survival for the entire cohort were 18 and 31 months. Conclusion: This is the largest reported series of primary CNS lymphoma (PCNSL) with intraocular involvement. Progression free and overall survival was similar to that reported with PCNSL. Dedicated ocular therapy improved disease control but did not affect overall survival.

AB - Objective: To describe the demographics, diagnostic details, therapeutic management, and outcome in patients with primary CNS lymphoma (PCNSL) with ocular involvement. Methods: A retrospective study of 221 patients was assembled from 16 centers in seven countries. Only HIV-negative, immunocompetent patients with brain and ocular lymphoma were included; none had systemic lymphoma. Results: Median age at diagnosis was 60. Fifty-seven percent were women. Median Eastern Cooperative Oncology Group performance status was 2. Ocular disturbance and behavioral/cognitive changes were the most common presenting symptoms. Diagnosis of lymphoma was made by brain biopsy (147), vitrectomy (65), or CSF cytology (11). Diagnosis of intraocular lymphoma was made by vitrectomy/choroidal/retinal biopsy (90) or clinical ophthalmic examination (141). CSF cytology was positive in 23%. Treatment information was available for 176 patients. A total of 102 received dedicated ocular therapy (ocular radiotherapy 79, intravitreal methotrexate 22, and both 1) in addition to treatment for their brain lymphoma. Sixty-nine percent progressed at a median of 13 months; sites of progression included brain 52%, eyes 19%, brain and eyes 12%, and systemic 2%. Patients treated with local ocular therapy did not have a statistically significant decreased risk of failing in the eyes (p ≤ 0.7). Median progression free survival and overall survival for the entire cohort were 18 and 31 months. Conclusion: This is the largest reported series of primary CNS lymphoma (PCNSL) with intraocular involvement. Progression free and overall survival was similar to that reported with PCNSL. Dedicated ocular therapy improved disease control but did not affect overall survival.

UR - http://www.scopus.com/inward/record.url?scp=55449111364&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55449111364&partnerID=8YFLogxK

U2 - 10.1212/01.wnl.0000327672.04729.8c

DO - 10.1212/01.wnl.0000327672.04729.8c

M3 - Article

C2 - 18936428

AN - SCOPUS:55449111364

SN - 0028-3878

VL - 71

SP - 1355

EP - 1360

JO - Neurology

JF - Neurology

IS - 17

ER -

Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this