Prevention of atopic dermatitis

Hywel C. Williams, Joanne R. Chalmers, Eric Simpson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Atopic dermatitis now affects one in five children, and may progress to asthma and hay fever. In the absence of effective treatments that influence disease progression, prevention is a highly desirable goal. The evidence for most existing disease prevention strategies, such as avoidance of allergens and dietary interventions, has been unconvincing and inconsistent. Fresh approaches to prevention include trying to induce tolerance to allergens in early life, and enhancing the defective skin barrier to reduce skin inflammation, sensitisation and subsequent allergic disease. Early and aggressive treatment of atopic dermatitis represents another possible secondary prevention strategy that could interrupt the development of autoimmunity, which may account for atopic dermatitis persistence. Large scale and long term randomized controlled trials are needed to demonstrate that these ideas result in clinical benefit.

Original languageEnglish (US)
Article number24
JournalF1000 Medicine Reports
Volume4
Issue number1
DOIs
StatePublished - Dec 3 2012

Fingerprint

Atopic Dermatitis
Allergens
Skin
Seasonal Allergic Rhinitis
Secondary Prevention
Autoimmunity
Disease Progression
Asthma
Randomized Controlled Trials
Inflammation
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevention of atopic dermatitis. / Williams, Hywel C.; Chalmers, Joanne R.; Simpson, Eric.

In: F1000 Medicine Reports, Vol. 4, No. 1, 24, 03.12.2012.

Research output: Contribution to journalArticle

Williams, Hywel C. ; Chalmers, Joanne R. ; Simpson, Eric. / Prevention of atopic dermatitis. In: F1000 Medicine Reports. 2012 ; Vol. 4, No. 1.
@article{123c9b7d9d404cd0a763868988ce1955,
title = "Prevention of atopic dermatitis",
abstract = "Atopic dermatitis now affects one in five children, and may progress to asthma and hay fever. In the absence of effective treatments that influence disease progression, prevention is a highly desirable goal. The evidence for most existing disease prevention strategies, such as avoidance of allergens and dietary interventions, has been unconvincing and inconsistent. Fresh approaches to prevention include trying to induce tolerance to allergens in early life, and enhancing the defective skin barrier to reduce skin inflammation, sensitisation and subsequent allergic disease. Early and aggressive treatment of atopic dermatitis represents another possible secondary prevention strategy that could interrupt the development of autoimmunity, which may account for atopic dermatitis persistence. Large scale and long term randomized controlled trials are needed to demonstrate that these ideas result in clinical benefit.",
author = "Williams, {Hywel C.} and Chalmers, {Joanne R.} and Eric Simpson",
year = "2012",
month = "12",
day = "3",
doi = "10.3410/M4-24",
language = "English (US)",
volume = "4",
journal = "F1000 Medicine Reports",
issn = "1757-5931",
publisher = "Medicine Reports Limited",
number = "1",

}

TY - JOUR

T1 - Prevention of atopic dermatitis

AU - Williams, Hywel C.

AU - Chalmers, Joanne R.

AU - Simpson, Eric

PY - 2012/12/3

Y1 - 2012/12/3

N2 - Atopic dermatitis now affects one in five children, and may progress to asthma and hay fever. In the absence of effective treatments that influence disease progression, prevention is a highly desirable goal. The evidence for most existing disease prevention strategies, such as avoidance of allergens and dietary interventions, has been unconvincing and inconsistent. Fresh approaches to prevention include trying to induce tolerance to allergens in early life, and enhancing the defective skin barrier to reduce skin inflammation, sensitisation and subsequent allergic disease. Early and aggressive treatment of atopic dermatitis represents another possible secondary prevention strategy that could interrupt the development of autoimmunity, which may account for atopic dermatitis persistence. Large scale and long term randomized controlled trials are needed to demonstrate that these ideas result in clinical benefit.

AB - Atopic dermatitis now affects one in five children, and may progress to asthma and hay fever. In the absence of effective treatments that influence disease progression, prevention is a highly desirable goal. The evidence for most existing disease prevention strategies, such as avoidance of allergens and dietary interventions, has been unconvincing and inconsistent. Fresh approaches to prevention include trying to induce tolerance to allergens in early life, and enhancing the defective skin barrier to reduce skin inflammation, sensitisation and subsequent allergic disease. Early and aggressive treatment of atopic dermatitis represents another possible secondary prevention strategy that could interrupt the development of autoimmunity, which may account for atopic dermatitis persistence. Large scale and long term randomized controlled trials are needed to demonstrate that these ideas result in clinical benefit.

UR - http://www.scopus.com/inward/record.url?scp=84873102418&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873102418&partnerID=8YFLogxK

U2 - 10.3410/M4-24

DO - 10.3410/M4-24

M3 - Article

VL - 4

JO - F1000 Medicine Reports

JF - F1000 Medicine Reports

SN - 1757-5931

IS - 1

M1 - 24

ER -