Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

MacRae F. Linton, James B. Atkinson, Sergio Fazio

Research output: Contribution to journalArticle

389 Citations (Scopus)

Abstract

Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin, apoE is synthesized by a variety of cell types, including macrophages. Because macrophages derive from hematopoietic cells, bone marrow transplantation was used to examine the potential of apoE synthesized by bone marrow-derived cells to correct the hyperlipidemia and atherosclerosis caused by apoE deficiency. After transplantation of bone marrow from mice with the normal apoE gene into apoE-deficient mice, apoE was detected in serum and promoted clearance of lipoproteins and normalization of serum cholesterol levels. ApoE-deficient mice given transplants of normal bone marrow showed virtually complete protection from diet-induced atherosclerosis.

Original languageEnglish (US)
Pages (from-to)1034-1037
Number of pages4
JournalScience
Volume267
Issue number5200
StatePublished - 1995
Externally publishedYes

Fingerprint

Apolipoproteins E
Bone Marrow Transplantation
Atherosclerosis
Hyperlipidemias
Macrophages
Serum
Bone Marrow Cells
Genes
Lipoproteins
Bone Marrow
Cholesterol
Diet
Transplants
Liver

ASJC Scopus subject areas

  • General

Cite this

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. / Linton, MacRae F.; Atkinson, James B.; Fazio, Sergio.

In: Science, Vol. 267, No. 5200, 1995, p. 1034-1037.

Research output: Contribution to journalArticle

Linton, MacRae F. ; Atkinson, James B. ; Fazio, Sergio. / Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation. In: Science. 1995 ; Vol. 267, No. 5200. pp. 1034-1037.
@article{cb8a7531e5aa4f6ca02fabb29fc33ca2,
title = "Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation",
abstract = "Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin, apoE is synthesized by a variety of cell types, including macrophages. Because macrophages derive from hematopoietic cells, bone marrow transplantation was used to examine the potential of apoE synthesized by bone marrow-derived cells to correct the hyperlipidemia and atherosclerosis caused by apoE deficiency. After transplantation of bone marrow from mice with the normal apoE gene into apoE-deficient mice, apoE was detected in serum and promoted clearance of lipoproteins and normalization of serum cholesterol levels. ApoE-deficient mice given transplants of normal bone marrow showed virtually complete protection from diet-induced atherosclerosis.",
author = "Linton, {MacRae F.} and Atkinson, {James B.} and Sergio Fazio",
year = "1995",
language = "English (US)",
volume = "267",
pages = "1034--1037",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5200",

}

TY - JOUR

T1 - Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

AU - Linton, MacRae F.

AU - Atkinson, James B.

AU - Fazio, Sergio

PY - 1995

Y1 - 1995

N2 - Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin, apoE is synthesized by a variety of cell types, including macrophages. Because macrophages derive from hematopoietic cells, bone marrow transplantation was used to examine the potential of apoE synthesized by bone marrow-derived cells to correct the hyperlipidemia and atherosclerosis caused by apoE deficiency. After transplantation of bone marrow from mice with the normal apoE gene into apoE-deficient mice, apoE was detected in serum and promoted clearance of lipoproteins and normalization of serum cholesterol levels. ApoE-deficient mice given transplants of normal bone marrow showed virtually complete protection from diet-induced atherosclerosis.

AB - Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin, apoE is synthesized by a variety of cell types, including macrophages. Because macrophages derive from hematopoietic cells, bone marrow transplantation was used to examine the potential of apoE synthesized by bone marrow-derived cells to correct the hyperlipidemia and atherosclerosis caused by apoE deficiency. After transplantation of bone marrow from mice with the normal apoE gene into apoE-deficient mice, apoE was detected in serum and promoted clearance of lipoproteins and normalization of serum cholesterol levels. ApoE-deficient mice given transplants of normal bone marrow showed virtually complete protection from diet-induced atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=0028944150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028944150&partnerID=8YFLogxK

M3 - Article

C2 - 7863332

AN - SCOPUS:0028944150

VL - 267

SP - 1034

EP - 1037

JO - Science

JF - Science

SN - 0036-8075

IS - 5200

ER -