Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

MacRae F. Linton, James B. Atkinson, Sergio Fazio

Research output: Contribution to journalArticlepeer-review

395 Scopus citations

Abstract

Apolipoprotein E (apoE) deficiency causes severe hyperlipidemia and atherosclerosis in humans and in gene-targeted mice. Although the majority of apoE in plasma is of hepatic origin, apoE is synthesized by a variety of cell types, including macrophages. Because macrophages derive from hematopoietic cells, bone marrow transplantation was used to examine the potential of apoE synthesized by bone marrow-derived cells to correct the hyperlipidemia and atherosclerosis caused by apoE deficiency. After transplantation of bone marrow from mice with the normal apoE gene into apoE-deficient mice, apoE was detected in serum and promoted clearance of lipoproteins and normalization of serum cholesterol levels. ApoE-deficient mice given transplants of normal bone marrow showed virtually complete protection from diet-induced atherosclerosis.

Original languageEnglish (US)
Pages (from-to)1034-1037
Number of pages4
JournalScience
Volume267
Issue number5200
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • General

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