Prevention and management of glucocorticoid-induced side effects: A comprehensive review: A review of glucocorticoid pharmacology and bone health

Avrom Caplan, Nicole Fett, Misha Rosenbach, Victoria P. Werth, Robert G. Micheletti

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Systemic glucocorticoids are an essential therapy for a range of conditions, but their multiple side effects can produce significant morbidity for patients. The objective of this review is to discuss these side effects while addressing 3 questions: 1) What dose and duration of glucocorticoid therapy should prompt concern for individual side effects?; 2) How should clinicians counsel patients about these complications?; and 3) How can these problems be prevented or managed? To accomplish these objectives, we have created a series of tables and algorithms based on a review of relevant data to guide counseling, prophylaxis, and management of 11 glucocorticoid side effects. The first article in this 4-part continuing medical education series begins with a review of glucocorticoid pharmacology followed by a discussion of bone health (ie, osteoporosis and osteonecrosis).

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume76
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • glucocorticoids
  • medication monitoring
  • osteonecrosis
  • osteoporosis
  • pharmacology
  • side effects
  • steroids

ASJC Scopus subject areas

  • Dermatology

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