Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta)

Jessica A. White, Patricia A. Todd, JoAnn L. Yee, Alexis Kalman-Bowlus, Kelsey S. Rodgers, Yang Xiaowei, Scott Wong, Peter Barry, Nicholas W. Lerche

Research output: Contribution to journalArticle

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Abstract

We performed a cross-sectional study to estimate the prevalence of 2 gamma-2-herpesviruses, rhesus rhadinovirus (RRV) and retroperitoneal fibromatosis herpesvirus (RFHV), in breeding colonies of rhesus macaques. Of 90 animals selected for sampling, 73 (81%) were positive for RRV, which was detected only in blood in 22 (24%), only in saliva in 15 (16%), and in both blood and saliva in 36 (40%). Detection of RRV DNA in blood and saliva was significantly higher in animals younger than 2 y. In comparison, RFHV was detected in 40 (44%) of the 90 animals: only in blood in 5 (6%), only in saliva in 26 (29%), and in both blood and saliva in 9 (10%). Dual infection was detected in 38 (42%) animals; RFHV was only detected in coinfections. The mean RRV genome copy number in blood was significantly higher than that for RFHV. Age was a significant predictor of RRV copy number in blood and RFHV copy number in saliva. Of the 90 animals, 88 (98%) were positive for rhadinoviral antibodies on an immunofluorescent assay. Both RRV and RFHV are highly endemic in socially housed breeding colonies of rhesus macaques, and their patterns of infection are similar to that for the betaherpesvirus rhesus cytomegalovirus.

Original languageEnglish (US)
Pages (from-to)383-390
Number of pages8
JournalComparative Medicine
Volume59
Issue number4
StatePublished - Aug 2009

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Macacine herpesvirus 5
Rhadinovirus
Fibroma
Herpesviridae
Viremia
viremia
Macaca mulatta
Breeding
saliva
mouth
Saliva
Blood
Animals
blood
breeding
animals
Cytomegalovirus
young animals
Infection
Coinfection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta). / White, Jessica A.; Todd, Patricia A.; Yee, JoAnn L.; Kalman-Bowlus, Alexis; Rodgers, Kelsey S.; Xiaowei, Yang; Wong, Scott; Barry, Peter; Lerche, Nicholas W.

In: Comparative Medicine, Vol. 59, No. 4, 08.2009, p. 383-390.

Research output: Contribution to journalArticle

White, Jessica A. ; Todd, Patricia A. ; Yee, JoAnn L. ; Kalman-Bowlus, Alexis ; Rodgers, Kelsey S. ; Xiaowei, Yang ; Wong, Scott ; Barry, Peter ; Lerche, Nicholas W. / Prevalence of viremia and oral shedding of rhesus rhadinovirus and retroperitoneal fibromatosis herpesvirus in large age-structured breeding groups of rhesus macaques (Macaca mulatta). In: Comparative Medicine. 2009 ; Vol. 59, No. 4. pp. 383-390.
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