Prevalence of pituitary hormone dysfunction, metabolic syndrome, and impaired quality of life in retired professional football players

A prospective study

Daniel F. Kelly, Charlene Chaloner, Diana Evans, Amy Mathews, Pejman Cohan, Christina Wang, Ronald Swerdloff, Myung Shin Sim, Jihey Lee, Mathew J. Wright, Claudia Kernan, Garni Barkhoudarian, Kevin C J Yuen, Kevin Guskiewicz

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Hypopituitarism is common after moderate and severe traumatic brain injury (TBI). Herein, we address the association between mild TBI (mTBI) and pituitary and metabolic function in retired football players. Retirees 30-65 years of age, with one or more years of National Football League (NFL) play and poor quality of life (QoL) based on Short Form 36 (SF-36) Mental Component Score (MCS) were prospectively enrolled. Pituitary hormonal and metabolic syndrome (MetS) testing was performed. Using a glucagon stimulation test, growth hormone deficiency (GHD) was defined with a standard cut point of 3 ng/mL and with a more stringent body mass index (BMI)-adjusted cut point. Subjects with and without hormonal deficiency (HD) were compared in terms of QoL, International Index of Erectile Function (IIEF) scores, metabolic parameters, and football career data. Of 74 subjects, 6 were excluded because of significant non-football-related TBIs. Of the remaining 68 subjects (mean age, 47.3±10.2 years; median NFL years, 5; median NFL concussions, 3; mean BMI, 33.8±6.0), 28 (41.2%) were GHD using a peak GH cutoff of

Original languageEnglish (US)
Pages (from-to)1161-1171
Number of pages11
JournalJournal of Neurotrauma
Volume31
Issue number13
DOIs
StatePublished - Jul 1 2014

Fingerprint

Pituitary Hormones
Football
Quality of Life
Prospective Studies
Growth Hormone
Body Mass Index
Brain Concussion
Hypopituitarism
Glucagon

Keywords

  • growth hormone deficiency
  • hypogonadism
  • metabolic syndrome
  • mild traumatic brain injury
  • professional football

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

Cite this

Prevalence of pituitary hormone dysfunction, metabolic syndrome, and impaired quality of life in retired professional football players : A prospective study. / Kelly, Daniel F.; Chaloner, Charlene; Evans, Diana; Mathews, Amy; Cohan, Pejman; Wang, Christina; Swerdloff, Ronald; Sim, Myung Shin; Lee, Jihey; Wright, Mathew J.; Kernan, Claudia; Barkhoudarian, Garni; Yuen, Kevin C J; Guskiewicz, Kevin.

In: Journal of Neurotrauma, Vol. 31, No. 13, 01.07.2014, p. 1161-1171.

Research output: Contribution to journalArticle

Kelly, DF, Chaloner, C, Evans, D, Mathews, A, Cohan, P, Wang, C, Swerdloff, R, Sim, MS, Lee, J, Wright, MJ, Kernan, C, Barkhoudarian, G, Yuen, KCJ & Guskiewicz, K 2014, 'Prevalence of pituitary hormone dysfunction, metabolic syndrome, and impaired quality of life in retired professional football players: A prospective study', Journal of Neurotrauma, vol. 31, no. 13, pp. 1161-1171. https://doi.org/10.1089/neu.2013.3212
Kelly, Daniel F. ; Chaloner, Charlene ; Evans, Diana ; Mathews, Amy ; Cohan, Pejman ; Wang, Christina ; Swerdloff, Ronald ; Sim, Myung Shin ; Lee, Jihey ; Wright, Mathew J. ; Kernan, Claudia ; Barkhoudarian, Garni ; Yuen, Kevin C J ; Guskiewicz, Kevin. / Prevalence of pituitary hormone dysfunction, metabolic syndrome, and impaired quality of life in retired professional football players : A prospective study. In: Journal of Neurotrauma. 2014 ; Vol. 31, No. 13. pp. 1161-1171.
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