Prevalence of left ventricular systolic dysfunction in adults with repaired tetralogy of fallot

Craig S. Broberg, Jamil Aboulhosn, Franois Pierre Mongeon, Joseph Kay, Anne Marie Valente, Paul Khairy, Michael G. Earing, Alexander R. Opotowsky, George Lui, Deborah R. Gersony, Stephen Cook, Jennifer Grando Ting, Gary Webb, Michelle Z. Gurvitz

    Research output: Contribution to journalArticlepeer-review

    125 Scopus citations


    Left ventricular (LV) systolic dysfunction has been observed in patients with repaired tetralogy of Fallot (TOF), although its clinical associations are unknown. Adults with repaired TOF were identified from 11 adult congenital heart disease centers. Clinical history was reviewed. Patients with pulmonary atresia were excluded. Echocardiograms were reanalyzed to estimate LV ejection fraction. LV function was defined as normal (LV ejection fraction <55%) or mildly (45% to 54%), moderately (35% to 44%), or severely (<35%) decreased. Right ventricular (RV) and LV dimensions and Doppler parameters were remeasured. Function of all valves was qualitatively scored. Of 511 patients studied, LV systolic dysfunction was present in 107 (20.9%, 95% confidence interval 17.4 to 24.5). Specifically, 74 (14.4%) had mildly decreased and 33 (6.3%) had moderately to severely decreased systolic function. Presence of moderate to severe LV dysfunction was associated with male gender, LV enlargement, duration of shunt before repair, history of arrhythmia, QRS duration, implanted cardioverterdefibrillator, and moderate to severe RV dysfunction. Severity or duration of pulmonary regurgitation was not different. In conclusion, LV systolic dysfunction was found in 21% of adult patients with TOF and was associated with shunt duration, RV dysfunction, and arrhythmia.

    Original languageEnglish (US)
    Pages (from-to)1215-1220
    Number of pages6
    JournalAmerican Journal of Cardiology
    Issue number8
    StatePublished - Apr 15 2011

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine


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