Prevalence of brain magnetic resonance imaging meeting Barkhof and McDonald criteria for dissemination in space among headache patients

Syrone Liu, Jonathan Kullnat, Dennis Bourdette, Jack Simon, Dale Kraemer, Charles Murchison, Bronwyn Hamilton

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: Incidental T2 white matter hyperintensities (WMHs) in headache patients on brain magnetic resonance imaging (MRI) may prompt concern for demyelinating disease. Objective: We reviewed brain MRI studies in patients with headaches without known demyelinating disease to determine the prevalence meeting imaging criteria for multiple sclerosis (MS) using two different definitions of "juxtacortical" and "periventricular". Methods: Consecutive patients undergoing pre- and post-contrast MRI for headaches over a 25-month period were retrospectively identified. Exclusions included patients under age 10 and over 55 years or with known demyelinating disorder. Patients were classified as meeting: 1) Barkhof and 2) 2010 McDonald dissemination in space criteria for MS based on: FLAIR/T2 scans for WMH and enhanced T1-weighted images for enhancement. Both groups were further differentiated by defining "periventricular" and " juxtacortical" as WMH contacting ventricle and cortex (Barkhof "touching", McDonald "touching") versus WMH within 3 mm (Barkhof - 3 mm, McDonald - 3 mm). Results: 326/564 (58%) studies met inclusion criteria. WMH prevalence was 168/326 (51.53%). Barkhof "touching" criteria were met in 4/168 (2.4%) and in 12/168 (7.1%) of the 3 mm group. McDonald criteria were met in 41/168 (24.4%) for "touching" and 58/168 (34.5%) for 3 mm, respectively. Conclusion: Barkhof and McDonald criteria were met in 2.4-7.1% and 24.4-34.5%, respectively.

Original languageEnglish (US)
Pages (from-to)1101-1105
Number of pages5
JournalMultiple Sclerosis
Volume19
Issue number8
DOIs
StatePublished - 2013

Fingerprint

Headache
Magnetic Resonance Imaging
Demyelinating Diseases
Brain
Multiple Sclerosis
Image Enhancement
White Matter

Keywords

  • clinically isolated syndrome
  • fluid attenuation inversion recovery
  • magnetic resonance imaging
  • Multiple sclerosis
  • radiologically isolated syndrome
  • white matter hyperintensity

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Prevalence of brain magnetic resonance imaging meeting Barkhof and McDonald criteria for dissemination in space among headache patients. / Liu, Syrone; Kullnat, Jonathan; Bourdette, Dennis; Simon, Jack; Kraemer, Dale; Murchison, Charles; Hamilton, Bronwyn.

In: Multiple Sclerosis, Vol. 19, No. 8, 2013, p. 1101-1105.

Research output: Contribution to journalArticle

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abstract = "Background: Incidental T2 white matter hyperintensities (WMHs) in headache patients on brain magnetic resonance imaging (MRI) may prompt concern for demyelinating disease. Objective: We reviewed brain MRI studies in patients with headaches without known demyelinating disease to determine the prevalence meeting imaging criteria for multiple sclerosis (MS) using two different definitions of {"}juxtacortical{"} and {"}periventricular{"}. Methods: Consecutive patients undergoing pre- and post-contrast MRI for headaches over a 25-month period were retrospectively identified. Exclusions included patients under age 10 and over 55 years or with known demyelinating disorder. Patients were classified as meeting: 1) Barkhof and 2) 2010 McDonald dissemination in space criteria for MS based on: FLAIR/T2 scans for WMH and enhanced T1-weighted images for enhancement. Both groups were further differentiated by defining {"}periventricular{"} and {"} juxtacortical{"} as WMH contacting ventricle and cortex (Barkhof {"}touching{"}, McDonald {"}touching{"}) versus WMH within 3 mm (Barkhof - 3 mm, McDonald - 3 mm). Results: 326/564 (58{\%}) studies met inclusion criteria. WMH prevalence was 168/326 (51.53{\%}). Barkhof {"}touching{"} criteria were met in 4/168 (2.4{\%}) and in 12/168 (7.1{\%}) of the 3 mm group. McDonald criteria were met in 41/168 (24.4{\%}) for {"}touching{"} and 58/168 (34.5{\%}) for 3 mm, respectively. Conclusion: Barkhof and McDonald criteria were met in 2.4-7.1{\%} and 24.4-34.5{\%}, respectively.",
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AU - Kraemer, Dale

AU - Murchison, Charles

AU - Hamilton, Bronwyn

PY - 2013

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N2 - Background: Incidental T2 white matter hyperintensities (WMHs) in headache patients on brain magnetic resonance imaging (MRI) may prompt concern for demyelinating disease. Objective: We reviewed brain MRI studies in patients with headaches without known demyelinating disease to determine the prevalence meeting imaging criteria for multiple sclerosis (MS) using two different definitions of "juxtacortical" and "periventricular". Methods: Consecutive patients undergoing pre- and post-contrast MRI for headaches over a 25-month period were retrospectively identified. Exclusions included patients under age 10 and over 55 years or with known demyelinating disorder. Patients were classified as meeting: 1) Barkhof and 2) 2010 McDonald dissemination in space criteria for MS based on: FLAIR/T2 scans for WMH and enhanced T1-weighted images for enhancement. Both groups were further differentiated by defining "periventricular" and " juxtacortical" as WMH contacting ventricle and cortex (Barkhof "touching", McDonald "touching") versus WMH within 3 mm (Barkhof - 3 mm, McDonald - 3 mm). Results: 326/564 (58%) studies met inclusion criteria. WMH prevalence was 168/326 (51.53%). Barkhof "touching" criteria were met in 4/168 (2.4%) and in 12/168 (7.1%) of the 3 mm group. McDonald criteria were met in 41/168 (24.4%) for "touching" and 58/168 (34.5%) for 3 mm, respectively. Conclusion: Barkhof and McDonald criteria were met in 2.4-7.1% and 24.4-34.5%, respectively.

AB - Background: Incidental T2 white matter hyperintensities (WMHs) in headache patients on brain magnetic resonance imaging (MRI) may prompt concern for demyelinating disease. Objective: We reviewed brain MRI studies in patients with headaches without known demyelinating disease to determine the prevalence meeting imaging criteria for multiple sclerosis (MS) using two different definitions of "juxtacortical" and "periventricular". Methods: Consecutive patients undergoing pre- and post-contrast MRI for headaches over a 25-month period were retrospectively identified. Exclusions included patients under age 10 and over 55 years or with known demyelinating disorder. Patients were classified as meeting: 1) Barkhof and 2) 2010 McDonald dissemination in space criteria for MS based on: FLAIR/T2 scans for WMH and enhanced T1-weighted images for enhancement. Both groups were further differentiated by defining "periventricular" and " juxtacortical" as WMH contacting ventricle and cortex (Barkhof "touching", McDonald "touching") versus WMH within 3 mm (Barkhof - 3 mm, McDonald - 3 mm). Results: 326/564 (58%) studies met inclusion criteria. WMH prevalence was 168/326 (51.53%). Barkhof "touching" criteria were met in 4/168 (2.4%) and in 12/168 (7.1%) of the 3 mm group. McDonald criteria were met in 41/168 (24.4%) for "touching" and 58/168 (34.5%) for 3 mm, respectively. Conclusion: Barkhof and McDonald criteria were met in 2.4-7.1% and 24.4-34.5%, respectively.

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KW - fluid attenuation inversion recovery

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KW - radiologically isolated syndrome

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