Prevalence of asymmetry of mamillary body and fornix size on MR imaging

Arzu Ozturk, David M. Yousem, A. Mahmood, S. El Sayed

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: Mamillary body and fornix asymmetry are frequent findings on MR imaging of the brain. We sought to determine the prevalence of asymmetry of the fornix and mamillary body on MR imaging in patients with or without seizures. MATERIALS AND METHODS: MR images were retrospectively evaluated for asymmetry of the mamillary body and fornix in 178 patients who had a history of seizures, of whom 35 had suspected mesial temporal sclerosis (MTS). Additionally, 353 patients who had no limbic system pathology were reviewed. All patients were examined with spin-echo MR imaging, consisting of contiguous axial and/or coronal fluid-attenuated inversion recovery (FLAIR), T2-weighted, and sagittal T1-weighted imaging. Additionally, the patients with seizures had oblique coronal 3-mm T2-weighted, FLAIR, and 1.5-mm magnetization-preparation rapid gradient echo scanning through their temporal lobes. RESULTS: In the patients who had no limbic system pathology or seizure history, 6.5% (23/353) had MR imaging evidence of asymmetric mamillary bodies and 7.9% (28/353) had asymmetric fornix size. Asymmetry of the mamillary body and fornix size was found in 37.1% (13/35) and 34.3% (12/35), respectively, of subjects with suggested hippocampal sclerosis. The prevalence of asymmetry of the mamillary body and fornix was statistically significantly higher in the patients with MTS (χ2 test, P <.0001). CONCLUSION: Although asymmetry of the mamillary bodies and fornices is highly associated with MTS, this could also be seen as a normal variation or congenital abnormality.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalAmerican Journal of Neuroradiology
Volume29
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

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Mammillary Bodies
Body Size
Sclerosis
Seizures
Limbic System
Pathology
Temporal Lobe
Neuroimaging
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Prevalence of asymmetry of mamillary body and fornix size on MR imaging. / Ozturk, Arzu; Yousem, David M.; Mahmood, A.; El Sayed, S.

In: American Journal of Neuroradiology, Vol. 29, No. 2, 02.2008, p. 384-387.

Research output: Contribution to journalArticle

Ozturk, Arzu ; Yousem, David M. ; Mahmood, A. ; El Sayed, S. / Prevalence of asymmetry of mamillary body and fornix size on MR imaging. In: American Journal of Neuroradiology. 2008 ; Vol. 29, No. 2. pp. 384-387.
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abstract = "BACKGROUND AND PURPOSE: Mamillary body and fornix asymmetry are frequent findings on MR imaging of the brain. We sought to determine the prevalence of asymmetry of the fornix and mamillary body on MR imaging in patients with or without seizures. MATERIALS AND METHODS: MR images were retrospectively evaluated for asymmetry of the mamillary body and fornix in 178 patients who had a history of seizures, of whom 35 had suspected mesial temporal sclerosis (MTS). Additionally, 353 patients who had no limbic system pathology were reviewed. All patients were examined with spin-echo MR imaging, consisting of contiguous axial and/or coronal fluid-attenuated inversion recovery (FLAIR), T2-weighted, and sagittal T1-weighted imaging. Additionally, the patients with seizures had oblique coronal 3-mm T2-weighted, FLAIR, and 1.5-mm magnetization-preparation rapid gradient echo scanning through their temporal lobes. RESULTS: In the patients who had no limbic system pathology or seizure history, 6.5{\%} (23/353) had MR imaging evidence of asymmetric mamillary bodies and 7.9{\%} (28/353) had asymmetric fornix size. Asymmetry of the mamillary body and fornix size was found in 37.1{\%} (13/35) and 34.3{\%} (12/35), respectively, of subjects with suggested hippocampal sclerosis. The prevalence of asymmetry of the mamillary body and fornix was statistically significantly higher in the patients with MTS (χ2 test, P <.0001). CONCLUSION: Although asymmetry of the mamillary bodies and fornices is highly associated with MTS, this could also be seen as a normal variation or congenital abnormality.",
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