Prevalence of anal human papillomavirus vaccine types in the Bangkok men who have sex with men cohort study

Ross D. Cranston, Andrew D. Althouse, Frits Van Griensven, Laura Janocko, Marcel Curlin, Supaporn Chaikummao, Wannee Chonwattana, Aaron Siegel, Timothy H. Holtz, Ian McGowan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The quadrivalent human papillomavirus (qHPV) and 9 valent (nHPV) vaccine are licensed for males to prevent anal HPV-associated dysplasia and cancer caused by HPV types 6, 11, 16, and 18 (qHPV) and additional types 33, 35, 45, 52, and 58 (nHPV), respectively. Both conditions are common in HIV-infected and HIV-uninfected men who have sex with men (MSM). It is not well documented which anal HPV vaccine types are most prevalent in Southeast Asia. Methods: A convenience sample of 400 anal swabs were obtained from 200 HIV-infected and 200 HIV-uninfected sexually active Bangkok MSM Cohort Study participants. After swab collection in PreservCyt (Cytyc Corp,Marlborough,MA), the media was stored at.80°C until processing. DNA was extracted, amplified by polymerase chain reaction, denatured, and then hybridized to probes for 37 HPV types and â-globin. Results: The mean participant age was 25.6 years (range, 18-55 years); the mean CD4 T-cell count was 410 cells/mm3 in the HIV-infected participants. Among all swab samples, 386 (192 HIV-positive and 194 HIVnegative) had adequate â-globin for HPV genotype testing. Anal HPV type was detected in 44.3% of participants whose samples underwent genotype testing. Both qHPVand nHPV types were more frequently detected in HIVinfected compared with HIV-uninfected (42.2% vs. 23.2% [P <0.01], 50.0% vs. 24.2% [P <0.01]), respectively). There were no significant relationships between social behaviors (alcohol use, drug use) or sexual behaviors (number of partners, condom usage, sexual positioning) and anal HPV prevalence. Conclusions: The prevalence of anal vaccine HPV types in Thai MSM was similar to that reported in MSM from Western populations and has a similar distribution by HIV status. Targeting youngMSMwith vaccination could offer protection against HPV vaccine types.

Original languageEnglish (US)
Pages (from-to)671-676
Number of pages6
JournalSexually Transmitted Diseases
Volume42
Issue number12
DOIs
StatePublished - 2015
Externally publishedYes

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Papillomavirus Vaccines
Cohort Studies
HIV
Globins
Genotype
Human papillomavirus 11
Human papillomavirus 6
Human papillomavirus 18
Southeastern Asia
Social Behavior
Condoms
CD4 Lymphocyte Count
Sexual Behavior
Vaccination
Vaccines
Alcohols
T-Lymphocytes
Polymerase Chain Reaction
DNA

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Prevalence of anal human papillomavirus vaccine types in the Bangkok men who have sex with men cohort study. / Cranston, Ross D.; Althouse, Andrew D.; Van Griensven, Frits; Janocko, Laura; Curlin, Marcel; Chaikummao, Supaporn; Chonwattana, Wannee; Siegel, Aaron; Holtz, Timothy H.; McGowan, Ian.

In: Sexually Transmitted Diseases, Vol. 42, No. 12, 2015, p. 671-676.

Research output: Contribution to journalArticle

Cranston, RD, Althouse, AD, Van Griensven, F, Janocko, L, Curlin, M, Chaikummao, S, Chonwattana, W, Siegel, A, Holtz, TH & McGowan, I 2015, 'Prevalence of anal human papillomavirus vaccine types in the Bangkok men who have sex with men cohort study', Sexually Transmitted Diseases, vol. 42, no. 12, pp. 671-676. https://doi.org/10.1097/OLQ.0000000000000372
Cranston, Ross D. ; Althouse, Andrew D. ; Van Griensven, Frits ; Janocko, Laura ; Curlin, Marcel ; Chaikummao, Supaporn ; Chonwattana, Wannee ; Siegel, Aaron ; Holtz, Timothy H. ; McGowan, Ian. / Prevalence of anal human papillomavirus vaccine types in the Bangkok men who have sex with men cohort study. In: Sexually Transmitted Diseases. 2015 ; Vol. 42, No. 12. pp. 671-676.
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abstract = "Background: The quadrivalent human papillomavirus (qHPV) and 9 valent (nHPV) vaccine are licensed for males to prevent anal HPV-associated dysplasia and cancer caused by HPV types 6, 11, 16, and 18 (qHPV) and additional types 33, 35, 45, 52, and 58 (nHPV), respectively. Both conditions are common in HIV-infected and HIV-uninfected men who have sex with men (MSM). It is not well documented which anal HPV vaccine types are most prevalent in Southeast Asia. Methods: A convenience sample of 400 anal swabs were obtained from 200 HIV-infected and 200 HIV-uninfected sexually active Bangkok MSM Cohort Study participants. After swab collection in PreservCyt (Cytyc Corp,Marlborough,MA), the media was stored at.80°C until processing. DNA was extracted, amplified by polymerase chain reaction, denatured, and then hybridized to probes for 37 HPV types and {\^a}-globin. Results: The mean participant age was 25.6 years (range, 18-55 years); the mean CD4 T-cell count was 410 cells/mm3 in the HIV-infected participants. Among all swab samples, 386 (192 HIV-positive and 194 HIVnegative) had adequate {\^a}-globin for HPV genotype testing. Anal HPV type was detected in 44.3{\%} of participants whose samples underwent genotype testing. Both qHPVand nHPV types were more frequently detected in HIVinfected compared with HIV-uninfected (42.2{\%} vs. 23.2{\%} [P <0.01], 50.0{\%} vs. 24.2{\%} [P <0.01]), respectively). There were no significant relationships between social behaviors (alcohol use, drug use) or sexual behaviors (number of partners, condom usage, sexual positioning) and anal HPV prevalence. Conclusions: The prevalence of anal vaccine HPV types in Thai MSM was similar to that reported in MSM from Western populations and has a similar distribution by HIV status. Targeting youngMSMwith vaccination could offer protection against HPV vaccine types.",
author = "Cranston, {Ross D.} and Althouse, {Andrew D.} and {Van Griensven}, Frits and Laura Janocko and Marcel Curlin and Supaporn Chaikummao and Wannee Chonwattana and Aaron Siegel and Holtz, {Timothy H.} and Ian McGowan",
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T1 - Prevalence of anal human papillomavirus vaccine types in the Bangkok men who have sex with men cohort study

AU - Cranston, Ross D.

AU - Althouse, Andrew D.

AU - Van Griensven, Frits

AU - Janocko, Laura

AU - Curlin, Marcel

AU - Chaikummao, Supaporn

AU - Chonwattana, Wannee

AU - Siegel, Aaron

AU - Holtz, Timothy H.

AU - McGowan, Ian

PY - 2015

Y1 - 2015

N2 - Background: The quadrivalent human papillomavirus (qHPV) and 9 valent (nHPV) vaccine are licensed for males to prevent anal HPV-associated dysplasia and cancer caused by HPV types 6, 11, 16, and 18 (qHPV) and additional types 33, 35, 45, 52, and 58 (nHPV), respectively. Both conditions are common in HIV-infected and HIV-uninfected men who have sex with men (MSM). It is not well documented which anal HPV vaccine types are most prevalent in Southeast Asia. Methods: A convenience sample of 400 anal swabs were obtained from 200 HIV-infected and 200 HIV-uninfected sexually active Bangkok MSM Cohort Study participants. After swab collection in PreservCyt (Cytyc Corp,Marlborough,MA), the media was stored at.80°C until processing. DNA was extracted, amplified by polymerase chain reaction, denatured, and then hybridized to probes for 37 HPV types and â-globin. Results: The mean participant age was 25.6 years (range, 18-55 years); the mean CD4 T-cell count was 410 cells/mm3 in the HIV-infected participants. Among all swab samples, 386 (192 HIV-positive and 194 HIVnegative) had adequate â-globin for HPV genotype testing. Anal HPV type was detected in 44.3% of participants whose samples underwent genotype testing. Both qHPVand nHPV types were more frequently detected in HIVinfected compared with HIV-uninfected (42.2% vs. 23.2% [P <0.01], 50.0% vs. 24.2% [P <0.01]), respectively). There were no significant relationships between social behaviors (alcohol use, drug use) or sexual behaviors (number of partners, condom usage, sexual positioning) and anal HPV prevalence. Conclusions: The prevalence of anal vaccine HPV types in Thai MSM was similar to that reported in MSM from Western populations and has a similar distribution by HIV status. Targeting youngMSMwith vaccination could offer protection against HPV vaccine types.

AB - Background: The quadrivalent human papillomavirus (qHPV) and 9 valent (nHPV) vaccine are licensed for males to prevent anal HPV-associated dysplasia and cancer caused by HPV types 6, 11, 16, and 18 (qHPV) and additional types 33, 35, 45, 52, and 58 (nHPV), respectively. Both conditions are common in HIV-infected and HIV-uninfected men who have sex with men (MSM). It is not well documented which anal HPV vaccine types are most prevalent in Southeast Asia. Methods: A convenience sample of 400 anal swabs were obtained from 200 HIV-infected and 200 HIV-uninfected sexually active Bangkok MSM Cohort Study participants. After swab collection in PreservCyt (Cytyc Corp,Marlborough,MA), the media was stored at.80°C until processing. DNA was extracted, amplified by polymerase chain reaction, denatured, and then hybridized to probes for 37 HPV types and â-globin. Results: The mean participant age was 25.6 years (range, 18-55 years); the mean CD4 T-cell count was 410 cells/mm3 in the HIV-infected participants. Among all swab samples, 386 (192 HIV-positive and 194 HIVnegative) had adequate â-globin for HPV genotype testing. Anal HPV type was detected in 44.3% of participants whose samples underwent genotype testing. Both qHPVand nHPV types were more frequently detected in HIVinfected compared with HIV-uninfected (42.2% vs. 23.2% [P <0.01], 50.0% vs. 24.2% [P <0.01]), respectively). There were no significant relationships between social behaviors (alcohol use, drug use) or sexual behaviors (number of partners, condom usage, sexual positioning) and anal HPV prevalence. Conclusions: The prevalence of anal vaccine HPV types in Thai MSM was similar to that reported in MSM from Western populations and has a similar distribution by HIV status. Targeting youngMSMwith vaccination could offer protection against HPV vaccine types.

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