Prevalence and predictors of hepatic steatosis in adults with newly diagnosed chronic liver disease due to hepatitis C

Amanda V. Hayman, Andre N. Sofair, M. Michele Manos, Ann Thomas, Norah Terrault, Grace Van Ness, Nicole Stabach, Marie Robert, Gregory Rumore, Christopher Corless, Beth Bell, Stephanie Bialek, Atif Zaman

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Abstract

Obesity appears to be a risk factor for hepatic steatosis, which has been implicated in the development of hepatic fibrosis in patients with hepatitis C virus infection. We conducted the current study to examine whether obesity is associated with hepatic steatosis among patients with chronic hepatitis C identified from a population-based cohort.Study participants were persons with chronic hepatitis C who had had a liver biopsy, identified from a population-based study of persons with newly identified chronic liver disease conducted in gastroenterology practices. Data were collected through patient interviews, medical record abstraction, and review of previously performed liver biopsies. The outcome variable of interest was significant steatosis, defined as steatosis grade 2 determined from liver biopsy samples. Univariate and multivariate analyses were performed using logistic regression techniques.The analysis included 450 patients with chronic hepatitis C with available liver biopsy slides. Overall, only 15.8% of subjects had significant hepatic steatosis (grade-2), while 35.9% of obese subjects had significant steatosis. In multivariate analysis, significant fibrosis (defined as-grade 2) (odds ratio [OR], 3.43; 95% confidence interval [CI], 1.59-7.37), obesity (OR, 3.32; 95% CI, 1.84-5.98), genotype 3 (OR, 2.5; 95% CI, 1.09-5.75), and the presence of multiple metabolic comorbidities (OR, 1.91; 95% CI, 0.88-4.11) were independently associated with steatosis.In this unique United States cohort of patients with newly diagnosed chronic liver disease due to hepatitis C, obesity was independently associated with hepatic steatosis. The results of this study provide additional evidence that obesity worsens liver damage in patients with chronic hepatitis C, and suggest a role for weight loss as a treatment modality in these patients.

Original languageEnglish (US)
Pages (from-to)302-306
Number of pages5
JournalMedicine
Volume88
Issue number5
DOIs
StatePublished - Sep 1 2009

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ASJC Scopus subject areas

  • Medicine(all)

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Hayman, A. V., Sofair, A. N., Manos, M. M., Thomas, A., Terrault, N., Ness, G. V., Stabach, N., Robert, M., Rumore, G., Corless, C., Bell, B., Bialek, S., & Zaman, A. (2009). Prevalence and predictors of hepatic steatosis in adults with newly diagnosed chronic liver disease due to hepatitis C. Medicine, 88(5), 302-306. https://doi.org/10.1097/MD.0b013e3181b954f4