Prevalence and determinants of hyperuricemia in middle-aged, Urban Chinese men

Raquel Villegas, Yong Bing Xiang, Qiuyin Cai, Sergio Fazio, MacRae Linton, Honglan Li, Tom Elasy, Wei Zheng, Xiao Ou Shu

Research output: Contribution to journalArticle

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Abstract

Background: Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease. We estimated the prevalence and lifestyle risk factors of hyperuricemia in middle-aged, urban Chinese men. Methods: The study included 3,978 urban Chinese men 40-74 years of age from a population-based cohort study, the Shanghai Men's Health Study, who were free of type 2 diabetes at baseline and had provided fasting blood samples. Uric acid concentrations were measured by the uricase method. Hyperuricemia was defined as >7.0 mg/dL. Anthropometric measurements and information on lifestyle factors and disease history were collected by in-person interviews. Results: One quarter of the study subjects had hyperuricemia. Participants with metabolic syndrome had a higher prevalence of hyperuricemia. Body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and weight gain (since age 20) were positively associated with the prevalence of hyperuricemia. Physical activity was inversely related to the prevalence of hyperuricemia. The odds ratios for hyperuricemia for quintiles of nonoccupational physical activity were 1.00, 0.80, 0.73, 0.75, and 0.57 (P trend

Original languageEnglish (US)
Pages (from-to)263-270
Number of pages8
JournalMetabolic Syndrome and Related Disorders
Volume8
Issue number3
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

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Hyperuricemia
Type 2 Diabetes Mellitus
Life Style
Urate Oxidase
Exercise
Men's Health
Waist-Hip Ratio
Waist Circumference
Uric Acid
Weight Gain
Fasting
Body Mass Index
Cohort Studies
Cardiovascular Diseases
Odds Ratio
Interviews

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Prevalence and determinants of hyperuricemia in middle-aged, Urban Chinese men. / Villegas, Raquel; Xiang, Yong Bing; Cai, Qiuyin; Fazio, Sergio; Linton, MacRae; Li, Honglan; Elasy, Tom; Zheng, Wei; Shu, Xiao Ou.

In: Metabolic Syndrome and Related Disorders, Vol. 8, No. 3, 01.06.2010, p. 263-270.

Research output: Contribution to journalArticle

Villegas, R, Xiang, YB, Cai, Q, Fazio, S, Linton, M, Li, H, Elasy, T, Zheng, W & Shu, XO 2010, 'Prevalence and determinants of hyperuricemia in middle-aged, Urban Chinese men', Metabolic Syndrome and Related Disorders, vol. 8, no. 3, pp. 263-270. https://doi.org/10.1089/met.2009.0084
Villegas, Raquel ; Xiang, Yong Bing ; Cai, Qiuyin ; Fazio, Sergio ; Linton, MacRae ; Li, Honglan ; Elasy, Tom ; Zheng, Wei ; Shu, Xiao Ou. / Prevalence and determinants of hyperuricemia in middle-aged, Urban Chinese men. In: Metabolic Syndrome and Related Disorders. 2010 ; Vol. 8, No. 3. pp. 263-270.
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