Prevalence and correlates of increased lung/heart ratio of thallium-201 during dipyridamole stress imaging for suspected coronary artery disease

Flordeliza S. Villanueva, Sanjiv Kaul, William H. Smith, Denny D. Watson, Shailendra K. Varma, George A. Beller

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Abstract

There is little information concerning the prevalence and clinical correlates of increased pulmonary thallium-201 uptake during dipyridamole thallium-201 stress imaging. Accordingly, the clinical characteristics and quantitative thallium-201 findings were correlated with quantitative lung/heart thallium-201 ratio in 87 patients undergoing dipyridamole thallium-201 stress testing. Nineteen patients (22%) had an elevated ratio (>0.51). These patients were more likely to have had an infarction, to be taking β blockers, and have a lower rate-pressure product after dipyridamole administration than those with a normal ratio (p <0.03). An elevated ratio was associated with a greater likelihood of initial, redistribution and persistent defects, as well as left ventricular cavity dilatation on thallium-201 imaging (p <0.05). In addition, the number of myocardial segments demonstrating initial, redistribution and persistent defects was also greater in patients with increased ratios (p <0.03). Multivariate analysis demonstrated that the presence of redistribution and left ventricular cavity dilatation were the most significant correlates of lung/heart thallium-201 ratio. It is concluded that the prevalence of increased lung/heart thallium-201 ratio with dipyridamole thallium-201 stress imaging is similar to that seen with exercise stress imaging. As with exercise thallium-201 imaging, increased pulmonary thallium-201 uptake may be a marker of functionally more significant coronary artery disease.

Original languageEnglish (US)
Pages (from-to)1324-1328
Number of pages5
JournalThe American Journal of Cardiology
Volume66
Issue number19
DOIs
StatePublished - Dec 1 1990
Externally publishedYes

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Dipyridamole
Thallium
Coronary Artery Disease
Lung
Dilatation
Exercise
Infarction
Multivariate Analysis
Pressure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Prevalence and correlates of increased lung/heart ratio of thallium-201 during dipyridamole stress imaging for suspected coronary artery disease. / Villanueva, Flordeliza S.; Kaul, Sanjiv; Smith, William H.; Watson, Denny D.; Varma, Shailendra K.; Beller, George A.

In: The American Journal of Cardiology, Vol. 66, No. 19, 01.12.1990, p. 1324-1328.

Research output: Contribution to journalArticle

Villanueva, Flordeliza S. ; Kaul, Sanjiv ; Smith, William H. ; Watson, Denny D. ; Varma, Shailendra K. ; Beller, George A. / Prevalence and correlates of increased lung/heart ratio of thallium-201 during dipyridamole stress imaging for suspected coronary artery disease. In: The American Journal of Cardiology. 1990 ; Vol. 66, No. 19. pp. 1324-1328.
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