Prevalence and correlates of increased lung/heart ratio of thallium-201 during dipyridamole stress imaging for suspected coronary artery disease

Flordeliza S. Villanueva, Sanjiv Kaul, William H. Smith, Denny D. Watson, Shailendra K. Varma, George A. Beller

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    Abstract

    There is little information concerning the prevalence and clinical correlates of increased pulmonary thallium-201 uptake during dipyridamole thallium-201 stress imaging. Accordingly, the clinical characteristics and quantitative thallium-201 findings were correlated with quantitative lung/heart thallium-201 ratio in 87 patients undergoing dipyridamole thallium-201 stress testing. Nineteen patients (22%) had an elevated ratio (>0.51). These patients were more likely to have had an infarction, to be taking β blockers, and have a lower rate-pressure product after dipyridamole administration than those with a normal ratio (p < 0.03). An elevated ratio was associated with a greater likelihood of initial, redistribution and persistent defects, as well as left ventricular cavity dilatation on thallium-201 imaging (p < 0.05). In addition, the number of myocardial segments demonstrating initial, redistribution and persistent defects was also greater in patients with increased ratios (p < 0.03). Multivariate analysis demonstrated that the presence of redistribution and left ventricular cavity dilatation were the most significant correlates of lung/heart thallium-201 ratio. It is concluded that the prevalence of increased lung/heart thallium-201 ratio with dipyridamole thallium-201 stress imaging is similar to that seen with exercise stress imaging. As with exercise thallium-201 imaging, increased pulmonary thallium-201 uptake may be a marker of functionally more significant coronary artery disease.

    Original languageEnglish (US)
    Pages (from-to)1324-1328
    Number of pages5
    JournalThe American journal of cardiology
    Volume66
    Issue number19
    DOIs
    StatePublished - Dec 1 1990

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    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

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