Prevalence and Correlates of Chlamydia trachomatis and Neisseria gonorrhoeae by Anatomic Site among Urban Thai Men Who Have Sex with Men

Jaray Tongtoyai, Catherine S. Todd, Wannee Chonwattana, Sarika Pattanasin, Supaporn Chaikummao, Anchalee Varangrat, Somchai Lokpichart, Timothy H. Holtz, Frits Van Griensven, Marcel Curlin

Research output: Contribution to journalArticle

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Abstract

Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection are prevalent among men who have sex with men (MSM) and may infect multiple anatomic sites. We measured site-specific prevalence and correlates of CTand NG infection among Bangkok MSMCohort Study participants. Methods: In April 2006 to November 2010, 1744 men enrolled in the Bangkok MSM Cohort Study. Participants provided historical information and underwent physical examination. Rectal, urethral, and pharyngeal CT and NG screeningwere performed by nucleic acid amplification and/or culture. Logistic regression was used to identify correlates of site-specific CT, NG, and coinfection. Results: Among 1743 participants, 19.2% were infected with CT and/or NG. CT, NG, and CT-NG coinfection were detected in 11.6%, 4.6%, and 2.9%, of participants, respectively. Rectal, urethral, and pharyngeal CT infections were detected in 9.5%, 4.5%, and 3.6% of cases. N. gonorrhoeae was present at these sites in 6.1%, 1.8%, and 0.5%of cases.Most infections were asymptomatic (CT: 95.3%, NG: 83.2%). Rectal CTand NG infections were mutually associated (CT: adjusted odds ratio [AOR], 5.4; 95% confidence interval [CI], 3.4-8.7; NG: AOR, 2.4; 95%CI, 1.1-5.2) and independently associated with HIVinfection (CT: AOR, 1.6, 95%CI, 1.0-2.4; NG: AOR, 2.0, 95% CI, 1.3-3.1). Numerous behavioral correlates of infection were observed. Conclusions: CT and NG infections are highly prevalent among MSM in Bangkok, most frequently affect the rectum, and are most often asymptomatic. Routine screening of asymptomatic MSM for CT and NG infection should include rectal sampling and focus on men with HIVand a history of other sexually transmitted infections.

Original languageEnglish (US)
Pages (from-to)440-449
Number of pages10
JournalSexually Transmitted Diseases
Volume42
Issue number8
DOIs
StatePublished - Aug 25 2015
Externally publishedYes

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Neisseria gonorrhoeae
Chlamydia trachomatis
Infection
Odds Ratio
Confidence Intervals
Coinfection
Chlamydia Infections
Asymptomatic Infections
Sexually Transmitted Diseases
Rectum
Nucleic Acids
Physical Examination

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Prevalence and Correlates of Chlamydia trachomatis and Neisseria gonorrhoeae by Anatomic Site among Urban Thai Men Who Have Sex with Men. / Tongtoyai, Jaray; Todd, Catherine S.; Chonwattana, Wannee; Pattanasin, Sarika; Chaikummao, Supaporn; Varangrat, Anchalee; Lokpichart, Somchai; Holtz, Timothy H.; Van Griensven, Frits; Curlin, Marcel.

In: Sexually Transmitted Diseases, Vol. 42, No. 8, 25.08.2015, p. 440-449.

Research output: Contribution to journalArticle

Tongtoyai, J, Todd, CS, Chonwattana, W, Pattanasin, S, Chaikummao, S, Varangrat, A, Lokpichart, S, Holtz, TH, Van Griensven, F & Curlin, M 2015, 'Prevalence and Correlates of Chlamydia trachomatis and Neisseria gonorrhoeae by Anatomic Site among Urban Thai Men Who Have Sex with Men', Sexually Transmitted Diseases, vol. 42, no. 8, pp. 440-449. https://doi.org/10.1097/OLQ.0000000000000311
Tongtoyai, Jaray ; Todd, Catherine S. ; Chonwattana, Wannee ; Pattanasin, Sarika ; Chaikummao, Supaporn ; Varangrat, Anchalee ; Lokpichart, Somchai ; Holtz, Timothy H. ; Van Griensven, Frits ; Curlin, Marcel. / Prevalence and Correlates of Chlamydia trachomatis and Neisseria gonorrhoeae by Anatomic Site among Urban Thai Men Who Have Sex with Men. In: Sexually Transmitted Diseases. 2015 ; Vol. 42, No. 8. pp. 440-449.
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title = "Prevalence and Correlates of Chlamydia trachomatis and Neisseria gonorrhoeae by Anatomic Site among Urban Thai Men Who Have Sex with Men",
abstract = "Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection are prevalent among men who have sex with men (MSM) and may infect multiple anatomic sites. We measured site-specific prevalence and correlates of CTand NG infection among Bangkok MSMCohort Study participants. Methods: In April 2006 to November 2010, 1744 men enrolled in the Bangkok MSM Cohort Study. Participants provided historical information and underwent physical examination. Rectal, urethral, and pharyngeal CT and NG screeningwere performed by nucleic acid amplification and/or culture. Logistic regression was used to identify correlates of site-specific CT, NG, and coinfection. Results: Among 1743 participants, 19.2{\%} were infected with CT and/or NG. CT, NG, and CT-NG coinfection were detected in 11.6{\%}, 4.6{\%}, and 2.9{\%}, of participants, respectively. Rectal, urethral, and pharyngeal CT infections were detected in 9.5{\%}, 4.5{\%}, and 3.6{\%} of cases. N. gonorrhoeae was present at these sites in 6.1{\%}, 1.8{\%}, and 0.5{\%}of cases.Most infections were asymptomatic (CT: 95.3{\%}, NG: 83.2{\%}). Rectal CTand NG infections were mutually associated (CT: adjusted odds ratio [AOR], 5.4; 95{\%} confidence interval [CI], 3.4-8.7; NG: AOR, 2.4; 95{\%}CI, 1.1-5.2) and independently associated with HIVinfection (CT: AOR, 1.6, 95{\%}CI, 1.0-2.4; NG: AOR, 2.0, 95{\%} CI, 1.3-3.1). Numerous behavioral correlates of infection were observed. Conclusions: CT and NG infections are highly prevalent among MSM in Bangkok, most frequently affect the rectum, and are most often asymptomatic. Routine screening of asymptomatic MSM for CT and NG infection should include rectal sampling and focus on men with HIVand a history of other sexually transmitted infections.",
author = "Jaray Tongtoyai and Todd, {Catherine S.} and Wannee Chonwattana and Sarika Pattanasin and Supaporn Chaikummao and Anchalee Varangrat and Somchai Lokpichart and Holtz, {Timothy H.} and {Van Griensven}, Frits and Marcel Curlin",
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T1 - Prevalence and Correlates of Chlamydia trachomatis and Neisseria gonorrhoeae by Anatomic Site among Urban Thai Men Who Have Sex with Men

AU - Tongtoyai, Jaray

AU - Todd, Catherine S.

AU - Chonwattana, Wannee

AU - Pattanasin, Sarika

AU - Chaikummao, Supaporn

AU - Varangrat, Anchalee

AU - Lokpichart, Somchai

AU - Holtz, Timothy H.

AU - Van Griensven, Frits

AU - Curlin, Marcel

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N2 - Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection are prevalent among men who have sex with men (MSM) and may infect multiple anatomic sites. We measured site-specific prevalence and correlates of CTand NG infection among Bangkok MSMCohort Study participants. Methods: In April 2006 to November 2010, 1744 men enrolled in the Bangkok MSM Cohort Study. Participants provided historical information and underwent physical examination. Rectal, urethral, and pharyngeal CT and NG screeningwere performed by nucleic acid amplification and/or culture. Logistic regression was used to identify correlates of site-specific CT, NG, and coinfection. Results: Among 1743 participants, 19.2% were infected with CT and/or NG. CT, NG, and CT-NG coinfection were detected in 11.6%, 4.6%, and 2.9%, of participants, respectively. Rectal, urethral, and pharyngeal CT infections were detected in 9.5%, 4.5%, and 3.6% of cases. N. gonorrhoeae was present at these sites in 6.1%, 1.8%, and 0.5%of cases.Most infections were asymptomatic (CT: 95.3%, NG: 83.2%). Rectal CTand NG infections were mutually associated (CT: adjusted odds ratio [AOR], 5.4; 95% confidence interval [CI], 3.4-8.7; NG: AOR, 2.4; 95%CI, 1.1-5.2) and independently associated with HIVinfection (CT: AOR, 1.6, 95%CI, 1.0-2.4; NG: AOR, 2.0, 95% CI, 1.3-3.1). Numerous behavioral correlates of infection were observed. Conclusions: CT and NG infections are highly prevalent among MSM in Bangkok, most frequently affect the rectum, and are most often asymptomatic. Routine screening of asymptomatic MSM for CT and NG infection should include rectal sampling and focus on men with HIVand a history of other sexually transmitted infections.

AB - Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection are prevalent among men who have sex with men (MSM) and may infect multiple anatomic sites. We measured site-specific prevalence and correlates of CTand NG infection among Bangkok MSMCohort Study participants. Methods: In April 2006 to November 2010, 1744 men enrolled in the Bangkok MSM Cohort Study. Participants provided historical information and underwent physical examination. Rectal, urethral, and pharyngeal CT and NG screeningwere performed by nucleic acid amplification and/or culture. Logistic regression was used to identify correlates of site-specific CT, NG, and coinfection. Results: Among 1743 participants, 19.2% were infected with CT and/or NG. CT, NG, and CT-NG coinfection were detected in 11.6%, 4.6%, and 2.9%, of participants, respectively. Rectal, urethral, and pharyngeal CT infections were detected in 9.5%, 4.5%, and 3.6% of cases. N. gonorrhoeae was present at these sites in 6.1%, 1.8%, and 0.5%of cases.Most infections were asymptomatic (CT: 95.3%, NG: 83.2%). Rectal CTand NG infections were mutually associated (CT: adjusted odds ratio [AOR], 5.4; 95% confidence interval [CI], 3.4-8.7; NG: AOR, 2.4; 95%CI, 1.1-5.2) and independently associated with HIVinfection (CT: AOR, 1.6, 95%CI, 1.0-2.4; NG: AOR, 2.0, 95% CI, 1.3-3.1). Numerous behavioral correlates of infection were observed. Conclusions: CT and NG infections are highly prevalent among MSM in Bangkok, most frequently affect the rectum, and are most often asymptomatic. Routine screening of asymptomatic MSM for CT and NG infection should include rectal sampling and focus on men with HIVand a history of other sexually transmitted infections.

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