Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin

Alfred J. Lewy, Brant P. Hasler, Jonathan S. Emens, Robert L. Sack

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

To date, we have entrained (synchronized) eight totally blind people with free-running circadian rhythms to a nightly dose of 10 mg of melatonin. Each person entrained at a different phase angle of entrainment (PAE), which is the interval in hours between the time of the melatonin dose and the time of the endogenous melatonin onset. When the PAE was plotted against the pretreatment free-running (i.e. slightly different than 24.0 h) circadian period (tau), the fitted regression line revealed a significant correlation, which is consistent with previous findings on light entrainment of rest-activity rhythms in free-running rodents.

Original languageEnglish (US)
Pages (from-to)158-160
Number of pages3
JournalNeuroscience Letters
Volume313
Issue number3
DOIs
StatePublished - Nov 9 2001

Keywords

  • Circadian period
  • Circadian phase
  • Melatonin
  • Melatonin amplitude
  • Melatonin assays
  • Melatonin onset (MO)
  • Phase angle of entrainment (PAE)
  • Tau

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Pretreatment circadian period in free-running blind people may predict the phase angle of entrainment to melatonin'. Together they form a unique fingerprint.

  • Cite this