Abstract
Hypothesis: Occult pretransplantation systemic inflammation will identify patients at risk for poor outcomes after renal transplantation. Design: Retrospective cohort study. Adhesion molecule levels were measured in pretransplantation serum samples from 86 recipients. Univariate and multivariate analyses were conducted to assess a possible correlation between serum adhesion molecule level and outcome. Setting: University referral center. Main Outcome Measures: Allograft rejection and survival. Results: Patients with low levels of vascular cell adhesion molecule 1 had less graft rejection (P=.007). Low levels of vascular cell adhesion molecule 1 independently predicted decreased rejection (relative risk, 0.17; P=.01), and high levels of vascular cell adhesion molecule 1 independently predicted graft loss (relative risk, 3.83; P=.02). Similar correlations were observed for intercellular adhesion molecule 1. Conclusions: Decreased pretransplantation adhesion molecule expression correlates with less rejection, and increased levels correlate with graft loss. Assessment of pretransplantation inflammatory status may be useful in optimizing immunosuppression therapy.
Original language | English (US) |
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Pages (from-to) | 1113-1120 |
Number of pages | 8 |
Journal | Archives of Surgery |
Volume | 138 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1 2003 |
ASJC Scopus subject areas
- Surgery