Pretransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation

Richard V. Perez, Charles Q. Huang, Jeremy R. Johnson, Brian J. Gallay, Mehul M. Gandhi, John P. McVicar, Christoph Troppmann, Susan Orloff, Chris E. Freise

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hypothesis: Occult pretransplantation systemic inflammation will identify patients at risk for poor outcomes after renal transplantation. Design: Retrospective cohort study. Adhesion molecule levels were measured in pretransplantation serum samples from 86 recipients. Univariate and multivariate analyses were conducted to assess a possible correlation between serum adhesion molecule level and outcome. Setting: University referral center. Main Outcome Measures: Allograft rejection and survival. Results: Patients with low levels of vascular cell adhesion molecule 1 had less graft rejection (P=.007). Low levels of vascular cell adhesion molecule 1 independently predicted decreased rejection (relative risk, 0.17; P=.01), and high levels of vascular cell adhesion molecule 1 independently predicted graft loss (relative risk, 3.83; P=.02). Similar correlations were observed for intercellular adhesion molecule 1. Conclusions: Decreased pretransplantation adhesion molecule expression correlates with less rejection, and increased levels correlate with graft loss. Assessment of pretransplantation inflammatory status may be useful in optimizing immunosuppression therapy.

Original languageEnglish (US)
Pages (from-to)1113-1120
Number of pages8
JournalArchives of Surgery
Volume138
Issue number10
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

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Vascular Cell Adhesion Molecule-1
Living Donors
Kidney Transplantation
Transplants
Graft Rejection
Intercellular Adhesion Molecule-1
Serum
Immunosuppression
Allografts
Cohort Studies
Referral and Consultation
Multivariate Analysis
Retrospective Studies
Outcome Assessment (Health Care)
Inflammation
Survival
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Perez, R. V., Huang, C. Q., Johnson, J. R., Gallay, B. J., Gandhi, M. M., McVicar, J. P., ... Freise, C. E. (2003). Pretransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation. Archives of Surgery, 138(10), 1113-1120. https://doi.org/10.1001/archsurg.138.10.1113

Pretransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation. / Perez, Richard V.; Huang, Charles Q.; Johnson, Jeremy R.; Gallay, Brian J.; Gandhi, Mehul M.; McVicar, John P.; Troppmann, Christoph; Orloff, Susan; Freise, Chris E.

In: Archives of Surgery, Vol. 138, No. 10, 01.10.2003, p. 1113-1120.

Research output: Contribution to journalArticle

Perez, RV, Huang, CQ, Johnson, JR, Gallay, BJ, Gandhi, MM, McVicar, JP, Troppmann, C, Orloff, S & Freise, CE 2003, 'Pretransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation', Archives of Surgery, vol. 138, no. 10, pp. 1113-1120. https://doi.org/10.1001/archsurg.138.10.1113
Perez, Richard V. ; Huang, Charles Q. ; Johnson, Jeremy R. ; Gallay, Brian J. ; Gandhi, Mehul M. ; McVicar, John P. ; Troppmann, Christoph ; Orloff, Susan ; Freise, Chris E. / Pretransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation. In: Archives of Surgery. 2003 ; Vol. 138, No. 10. pp. 1113-1120.
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