Pretransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation

Richard V. Perez, Charles Q. Huang, Jeremy R. Johnson, Brian J. Gallay, Mehul M. Gandhi, John P. McVicar, Christoph Troppmann, Susan L. Orloff, Chris E. Freise

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Hypothesis: Occult pretransplantation systemic inflammation will identify patients at risk for poor outcomes after renal transplantation. Design: Retrospective cohort study. Adhesion molecule levels were measured in pretransplantation serum samples from 86 recipients. Univariate and multivariate analyses were conducted to assess a possible correlation between serum adhesion molecule level and outcome. Setting: University referral center. Main Outcome Measures: Allograft rejection and survival. Results: Patients with low levels of vascular cell adhesion molecule 1 had less graft rejection (P=.007). Low levels of vascular cell adhesion molecule 1 independently predicted decreased rejection (relative risk, 0.17; P=.01), and high levels of vascular cell adhesion molecule 1 independently predicted graft loss (relative risk, 3.83; P=.02). Similar correlations were observed for intercellular adhesion molecule 1. Conclusions: Decreased pretransplantation adhesion molecule expression correlates with less rejection, and increased levels correlate with graft loss. Assessment of pretransplantation inflammatory status may be useful in optimizing immunosuppression therapy.

Original languageEnglish (US)
Pages (from-to)1113-1120
Number of pages8
JournalArchives of Surgery
Volume138
Issue number10
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Surgery

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    Perez, R. V., Huang, C. Q., Johnson, J. R., Gallay, B. J., Gandhi, M. M., McVicar, J. P., Troppmann, C., Orloff, S. L., & Freise, C. E. (2003). Pretransplantation soluble adhesion molecule expression predicts outcome after living donor renal transplantation. Archives of Surgery, 138(10), 1113-1120. https://doi.org/10.1001/archsurg.138.10.1113