Abstract
A recently described triple-transgenic mouse model (3xTg, PS1 M146V, APPSwe, and tauP301L) develops a neuropathology similar to the brains of Alzheimer's disease patients including progressive deposits of plaques and tangles [Neuron 39 (2003) 409]. These mice also show age-related deficits in hippocampal synaptic plasticity that occurs before the development of plaques and tangles. Here we report unchanged synaptic vesicle recycling, as measured by FM1-43 release, in the hippocampal neurons of the 3xTg mice. Expression levels of presynaptic protein synaptophysin and of proteins involved in synaptic vesicle recycling including AP180, dynamin I, and synaptotagmin I also remain unaffected. These data suggest that the synaptic deficits observed in the 3xTg neurons may not arise from the preserved synaptic vesicle recycling.
Original language | English (US) |
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Pages (from-to) | 34-38 |
Number of pages | 5 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 330 |
Issue number | 1 |
DOIs | |
State | Published - Apr 29 2005 |
Externally published | Yes |
Keywords
- Alzheimer's disease
- FM1-43 release
- Synapse
- Synaptic vesicle recycling
- Triple-transgenic mouse model
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology