Preserved synaptic vesicle recycling in hippocampal neurons in a mouse Alzheimer's disease model

Pamela J. Yao, Ittai Bushlin, Katsutoshi Furukawa

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A recently described triple-transgenic mouse model (3xTg, PS1 M146V, APPSwe, and tauP301L) develops a neuropathology similar to the brains of Alzheimer's disease patients including progressive deposits of plaques and tangles [Neuron 39 (2003) 409]. These mice also show age-related deficits in hippocampal synaptic plasticity that occurs before the development of plaques and tangles. Here we report unchanged synaptic vesicle recycling, as measured by FM1-43 release, in the hippocampal neurons of the 3xTg mice. Expression levels of presynaptic protein synaptophysin and of proteins involved in synaptic vesicle recycling including AP180, dynamin I, and synaptotagmin I also remain unaffected. These data suggest that the synaptic deficits observed in the 3xTg neurons may not arise from the preserved synaptic vesicle recycling.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume330
Issue number1
DOIs
StatePublished - Apr 29 2005
Externally publishedYes

Keywords

  • Alzheimer's disease
  • FM1-43 release
  • Synapse
  • Synaptic vesicle recycling
  • Triple-transgenic mouse model

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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