Preserved neurogenesis in non-demented individuals with AD neuropathology

David Briley, Valeria Ghirardi, Randall (Randy) Woltjer, Alicia Renck, Olga Zolochevska, Giulio Taglialatela, Maria Adelaide Micci

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel strategies to treat AD-related dementia. In the pursuit of this goal, we determined the number of hippocampal neural stem cells (NSCs) and investigated the expression of several miRNAs in NDAN and AD subjects. Laser-capture microdissection of autopsy human hippocampus DG and qRT-PCR miRNA analyses were combined with immunofluorescence in this study. The number of SOX2+ NSCs in the DG was significantly increased in NDAN individuals as compared to AD subjects. Further, the prevalence of SOX2+ NSCs was found to correlate with cognitive capacity. Neurogenesis-regulating miRNAs were decreased in NDAN individuals as compared to AD patients. An increased number of NSCs and new neurons in NDAN individuals is associated with a unique expression of regulating miRNAs and strongly support a role of neurogenesis in mediating, in part, the ability of these individuals to resist the pathological burden of AD.

Original languageEnglish (US)
Article number27812
JournalScientific Reports
Volume6
DOIs
StatePublished - Jun 14 2016

Fingerprint

Neurogenesis
Alzheimer Disease
Neural Stem Cells
MicroRNAs
Neuropathology
Laser Capture Microdissection
Aptitude
Fluorescent Antibody Technique
Dementia
Autopsy
Hippocampus
Neurons
Polymerase Chain Reaction

ASJC Scopus subject areas

  • General

Cite this

Briley, D., Ghirardi, V., Woltjer, R. R., Renck, A., Zolochevska, O., Taglialatela, G., & Micci, M. A. (2016). Preserved neurogenesis in non-demented individuals with AD neuropathology. Scientific Reports, 6, [27812]. https://doi.org/10.1038/srep27812

Preserved neurogenesis in non-demented individuals with AD neuropathology. / Briley, David; Ghirardi, Valeria; Woltjer, Randall (Randy); Renck, Alicia; Zolochevska, Olga; Taglialatela, Giulio; Micci, Maria Adelaide.

In: Scientific Reports, Vol. 6, 27812, 14.06.2016.

Research output: Contribution to journalArticle

Briley, D, Ghirardi, V, Woltjer, RR, Renck, A, Zolochevska, O, Taglialatela, G & Micci, MA 2016, 'Preserved neurogenesis in non-demented individuals with AD neuropathology', Scientific Reports, vol. 6, 27812. https://doi.org/10.1038/srep27812
Briley D, Ghirardi V, Woltjer RR, Renck A, Zolochevska O, Taglialatela G et al. Preserved neurogenesis in non-demented individuals with AD neuropathology. Scientific Reports. 2016 Jun 14;6. 27812. https://doi.org/10.1038/srep27812
Briley, David ; Ghirardi, Valeria ; Woltjer, Randall (Randy) ; Renck, Alicia ; Zolochevska, Olga ; Taglialatela, Giulio ; Micci, Maria Adelaide. / Preserved neurogenesis in non-demented individuals with AD neuropathology. In: Scientific Reports. 2016 ; Vol. 6.
@article{c2ed0809019e4d8eb9f3bac39252a04e,
title = "Preserved neurogenesis in non-demented individuals with AD neuropathology",
abstract = "Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel strategies to treat AD-related dementia. In the pursuit of this goal, we determined the number of hippocampal neural stem cells (NSCs) and investigated the expression of several miRNAs in NDAN and AD subjects. Laser-capture microdissection of autopsy human hippocampus DG and qRT-PCR miRNA analyses were combined with immunofluorescence in this study. The number of SOX2+ NSCs in the DG was significantly increased in NDAN individuals as compared to AD subjects. Further, the prevalence of SOX2+ NSCs was found to correlate with cognitive capacity. Neurogenesis-regulating miRNAs were decreased in NDAN individuals as compared to AD patients. An increased number of NSCs and new neurons in NDAN individuals is associated with a unique expression of regulating miRNAs and strongly support a role of neurogenesis in mediating, in part, the ability of these individuals to resist the pathological burden of AD.",
author = "David Briley and Valeria Ghirardi and Woltjer, {Randall (Randy)} and Alicia Renck and Olga Zolochevska and Giulio Taglialatela and Micci, {Maria Adelaide}",
year = "2016",
month = "6",
day = "14",
doi = "10.1038/srep27812",
language = "English (US)",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Preserved neurogenesis in non-demented individuals with AD neuropathology

AU - Briley, David

AU - Ghirardi, Valeria

AU - Woltjer, Randall (Randy)

AU - Renck, Alicia

AU - Zolochevska, Olga

AU - Taglialatela, Giulio

AU - Micci, Maria Adelaide

PY - 2016/6/14

Y1 - 2016/6/14

N2 - Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel strategies to treat AD-related dementia. In the pursuit of this goal, we determined the number of hippocampal neural stem cells (NSCs) and investigated the expression of several miRNAs in NDAN and AD subjects. Laser-capture microdissection of autopsy human hippocampus DG and qRT-PCR miRNA analyses were combined with immunofluorescence in this study. The number of SOX2+ NSCs in the DG was significantly increased in NDAN individuals as compared to AD subjects. Further, the prevalence of SOX2+ NSCs was found to correlate with cognitive capacity. Neurogenesis-regulating miRNAs were decreased in NDAN individuals as compared to AD patients. An increased number of NSCs and new neurons in NDAN individuals is associated with a unique expression of regulating miRNAs and strongly support a role of neurogenesis in mediating, in part, the ability of these individuals to resist the pathological burden of AD.

AB - Rare individuals remain cognitively intact despite the presence of neuropathology usually associated with fully symptomatic Alzheimer's disease (AD), which we refer to as Non-Demented with Alzheimer's disease Neuropathology (NDAN). Understanding the involved mechanism(s) of their cognitive resistance may reveal novel strategies to treat AD-related dementia. In the pursuit of this goal, we determined the number of hippocampal neural stem cells (NSCs) and investigated the expression of several miRNAs in NDAN and AD subjects. Laser-capture microdissection of autopsy human hippocampus DG and qRT-PCR miRNA analyses were combined with immunofluorescence in this study. The number of SOX2+ NSCs in the DG was significantly increased in NDAN individuals as compared to AD subjects. Further, the prevalence of SOX2+ NSCs was found to correlate with cognitive capacity. Neurogenesis-regulating miRNAs were decreased in NDAN individuals as compared to AD patients. An increased number of NSCs and new neurons in NDAN individuals is associated with a unique expression of regulating miRNAs and strongly support a role of neurogenesis in mediating, in part, the ability of these individuals to resist the pathological burden of AD.

UR - http://www.scopus.com/inward/record.url?scp=84974817380&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974817380&partnerID=8YFLogxK

U2 - 10.1038/srep27812

DO - 10.1038/srep27812

M3 - Article

VL - 6

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 27812

ER -